Relistor

Pronunciation

Generic Name: methylnaltrexone (METh IL nal TREX own)
Brand Names: Relistor

What is Relistor?

Relistor (methylnaltrexone) is a special narcotic drug that blocks certain effects of other narcotic medicines.

Relistor reduces constipation caused by narcotic medications that are often used to treat pain in people with terminal illness.

Relistor works by preventing this side effect without reducing the pain-relieving effects of the narcotic. It is usually given after laxatives have been tried without successful treatment of constipation.

Relistor may also be used for purposes other than those listed in this medication guide.

Important information

You should not use Relistor if you are allergic to methylnaltrexone, or if you have a blockage in your stomach or intestines.

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Before you use Relistor, tell your doctor if you have severe or ongoing diarrhea.

Prepare your Relistor dose in a syringe only when you are ready to give yourself an injection. After loading a syringe, if you cannot give the injection right away keep it at room temperature and use it within 24 hours.

Before receiving Relistor

You should not use Relistor if you are allergic to methylnaltrexone, or if you have a blockage in your stomach or intestines.

To make sure you can safely use Relistor, tell your doctor if you have any of these other conditions:

  • cancer;

  • a stomach ulcer; or

  • colitis or other intestinal disorder.

FDA pregnancy category B. Relistor is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether methylnaltrexone passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

See also: Pregnancy and breastfeeding warnings (in more detail)

How is Relistor used?

Relistor is injected under the skin. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

This medication is usually given once every other day, but not more often than once every 24 hours.

Relistor can produce a bowel movement within 30 minutes after injection.

Prepare your Relistor dose in a syringe only when you are ready to give yourself an injection. After loading a syringe, if you cannot give the injection right away keep it at room temperature and use it within 24 hours.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Each single use vial (bottle) of Relistor is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.

Relistor should look clear or slightly yellow in color. Do not use the medication if it has changed colors or has any particles in it. Call your doctor for a new prescription.

Store Relistor at room temperature away from moisture, heat, and light. Do not freeze.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

Do not use this medication more than once in a 24-hour period.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme dizziness, or feeling like you might pass out.

What should I avoid?

Relistor can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Do not use any other laxatives that your doctor has not prescribed.

Relistor side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Relistor: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have severe or ongoing diarrhea, stomach pain that will not go away, black or bloody stools, coughing up blood, or nausea or vomiting that are new or worsening symptoms.

Less serious Relistor side effects may include:

  • stomach pain, gas;

  • mild nausea or diarrhea;

  • dizziness; or

  • increased sweating.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Relistor?

Before receiving Relistor, tell your doctor if you use any narcotic medication, such as:

  • buprenorphine (Buprenex, Subutex);

  • butorphanol (Stadol);

  • codeine (Tylenol with codeine);

  • hydrocodone (Lortab, Vicodin);

  • hydromorphone (Dilaudid);

  • levorphanol (Levo-Dromoran);

  • meperidine (Demerol);

  • methadone (Dolophine, Methadose);

  • morphine (Kadian, MS Contin, Roxanol);

  • nalbuphine (Nubain);

  • naloxone (Narcan);

  • oxycodone (OxyContin, Roxicodone, Percocet);

  • oxymorphone (Numorphan); or

  • propoxyphene (Darvon, Darvocet).

This list is not complete and there may be other drugs that can interact with Relistor. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about Relistor injection.
  • Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

Copyright 1996-2014 Cerner Multum, Inc. Version: 4.02. Revision Date: 2012-04-18, 3:35:49 PM.

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