Probenecid Side Effects
Some side effects of probenecid may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to probenecid: oral tablet
Along with its needed effects, probenecid may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking probenecid:Rare
- Fast or irregular breathing
- puffiness or swellings of the eyelids or around the eyes
- shortness of breath, troubled breathing, tightness in chest, or wheezing
- changes in the skin color of the face occurring together with any of the other side effects listed here
- or skin rash, hives, or itching occurring together with any of the other side effects listed here
Check with your doctor as soon as possible if any of the following side effects occur while taking probenecid:Less common
- Bloody urine
- difficult or painful urination
- lower back or side pain (especially if severe or sharp)
- skin rash, hives, or itching (occurring without other signs of an allergic reaction)
- Cloudy urine
- cough or hoarseness
- fast or irregular breathing
- pain in back and/or ribs
- sores, ulcers, or white spots on lips or in mouth
- sore throat and fever with or without chills
- sudden decrease in the amount of urine
- swelling of face, fingers, feet, and/or lower legs
- swollen and/or painful glands
- unusual bleeding or bruising
- unusual tiredness or weakness
- yellow eyes or skin
- weight gain
Some side effects of probenecid may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- joint pain, redness, or swelling
- loss of appetite
- nausea or vomiting (mild)
- flushing or redness of face (occurring without any signs of an allergic reaction)
- frequent urge to urinate
- sore gums
For Healthcare Professionals
Applies to probenecid: oral tablet
In therapeutic doses, probenecid is generally well tolerated and has a low incidence of side effects.
An increase in acute attacks of gout may occur on initiation of probenecid therapy. The concomitant administration of colchicine or a nonsteroidal anti-inflammatory agent, where appropriate, may decrease the risk of this complication.
Adequate hydration, to result in urine output of 2 liters per day, if possible, and alkalinization of the urine may reduce the risk of stone formation.
Renal side effects have included renal colic, nephrotic syndrome, with or without renal failure, and urinary frequency. In addition, increased concentrations of uric acid in the renal tubules, due to probenecid therapy, may promote development of uric acid stones.
Hypersensitivity reactions may be severe. It has been reported that the risk of severe allergic reactions may be increased in patients previously treated with probenecid. In these cases, onset of hypersensitivity reactions is within several hours after reintroduction of probenecid therapy.
Hypersensitivity side effects have included rash, pruritus, fever, urticaria, and anaphylaxis.
Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency may increase the risk of probenecid-induced hemolytic anemia in some patients. However, probenecid has also been implicated in at least two cases of immune-mediated hemolytic anemia. In both cases, serum antibodies reacted with red blood cells only in the presence of probenecid. In one patient, a generalized rash, fever, malaise, and anorexia were also present.
Hematologic side effects have rarely included hemolytic anemia, aplastic anemia, leukopenia, and anemia.
Hepatic side effects have included hepatic necrosis.
Gastrointestinal side effects have included anorexia, nausea, sore gums, and vomiting.
Nervous system side effects have included headache and dizziness.
Dermatologic side effects including dermatitis, alopecia, and flushing have been reported.
Genitourinary side effects including costovertebral pain have been reported.
More about probenecid
- Other brands: Benemid
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