Probenecid Pregnancy and Breastfeeding Warnings

Probenecid is also known as: Benemid

Probenecid Pregnancy Warnings

Probenecid has been assigned to a pregnancy category B by the FDA. There are no controlled data in human pregnancy. Probenecid is known to cross the placental barrier. Probenecid is only recommended for use during pregnancy when benefit outweighs risk.

Case reports of probenecid use throughout pregnancy for the treatment of hyperuricemia associated with gout and renal dysfunction have not documented probenecid-induced adverse fetal outcome. In addition, one study evaluating the efficacy of single-dose ampicillin plus probenecid for the treatment of urinary tract infection during pregnancy failed to reveal evidence of adverse fetal effects. However, further data are required to fully evaluate the safety of probenecid therapy during pregnancy.

Probenecid Breastfeeding Warnings

A breast-fed infant of a 30-year-old female being treated with oral probenecid and cephalexin for a breast infection developed severe diarrhea and associated symptoms. The average concentrations of probenecid and cephalexin in milk were 964 and 745 mcg/L, respectively, corresponding to absolute and relative infant doses of 145 mcg/kg/day and 0.7% for probenecid and 112 mcg/kg/day and 0.5% for cephalexin. The infant's side effects were rated as possible for probenecid and probable for cephalexin based on the Naranjo probability scale.

There are no data on the excretion of probenecid into human milk. However, probenecid has been reported to be excreted into human milk in at least one patient.

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