Prandin Side Effects
Generic Name: repaglinide
Note: This document contains side effect information about repaglinide. Some of the dosage forms listed on this page may not apply to the brand name Prandin.
Some side effects of Prandin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to repaglinide: oral tablet
Along with its needed effects, repaglinide (the active ingredient contained in Prandin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking repaglinide:More common
- Convulsions (seizures)
Check with your doctor as soon as possible if any of the following side effects occur while taking repaglinide:More common
- low blood sugar, including anxious feeling, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool pale skin, difficulty in thinking, drowsiness, excessive hunger, fast heartbeat, headache, nausea, nervousness, nightmares, restless sleep, shakiness, slurred speech, or unusual tiredness or weakness
- pain in the chest
- runny or stuffy nose
- shortness of breath
- sinus congestion with pain
- sore throat
- Bloody or cloudy urine
- burning, painful, or difficult urination
- chest pain
- frequent urge to urinate
- problems with teeth
- skin rash, itching, or hives
- tearing of eyes
- tightness in chest
- trouble in breathing
- Black, tarry stools
- blood in stools
- fast or irregular heartbeat
- lower back or side pain
- pinpoint red spots on skin
- unusual bleeding or bruising
Some side effects of repaglinide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Back pain
- joint pain
- feeling of burning, numbness, tightness, tingling, warmth, or heat
For Healthcare Professionals
Applies to repaglinide: oral tablet
Repaglinide has been usually well tolerated. Over one year, 13% of patients treated with repaglinide (the active ingredient contained in Prandin) in clinical trials discontinued due to adverse events.
Metabolic side effects have included hypoglycemia, an extension of repaglinide (the active ingredient contained in Prandin) s pharmacologic effects. Hypoglycemia occurred in 16% of patients treated with repaglinide. Patients with liver disease may be at an increased risk of hypoglycemia due to diminished gluconeogenic capacity.
Cardiovascular side effects have included angina and chest pain which were reported in 1.8% of patients treated over one year. The overall incidence of other cardiovascular events including hypertension, abnormal EKG, myocardial infarction, arrhythmias, and palpitations was less than 1%.
The incidence of serious cardiovascular adverse events, including ischemia, was higher for repaglinide (the active ingredient contained in Prandin) (4%) than for sulfonylurea drugs (3%) in controlled comparator clinical trials. In one year controlled trials, repaglinide was not associated with increased mortality rates compared to rates observed with other oral hypoglycemic agents.
Hypersensitivity side effects during clinical trials involving 2,931 patients include one patient who experienced an anaphylactoid reaction.
Gastrointestinal side effects have included nausea, vomiting, diarrhea, constipation, and dyspepsia which occurred in up to 5% of patients in clinical trials.
Nervous system side effects have included headache which was reported with an incidence of 9% to 11% in patients taking repaglinide (the active ingredient contained in Prandin) compared to 10% in placebo treated patients. Paresthesia was also reported with an incidence of 2% to 3%.
Musculoskeletal side effects have included back pain and arthralgia which were reported in 5% and 6% of patients, respectively.
Respiratory side effects have included upper respiratory infection, sinusitis, rhinitis, and bronchitis which were reported in 2% to 16% of patients. These frequencies were similar to those reported for placebo-treated and sulfonylurea-treated patients.
Hepatic side effects have included elevated liver enzymes which were reported in less than 1% of patients in clinical trials. Additionally, there have been case reports of acute hepatotoxicity and cholestatic hepatitis.
Postmarketing experience has included reports of severe hepatic dysfunction including jaundice and hepatitis.
Hematologic side effects have included thrombocytopenia and leukopenia which were reported in less than 1% of patients.
Ocular side effects have included blurred vision and visual disturbances, especially at the initiation of treatment.
More about Prandin (repaglinide)
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