Nateglinide Side Effects

Brand Names: Starlix

Please note - some side effects for Nateglinide may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Nateglinide - for the Consumer

Nateglinide

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Nateglinide:

Changes in vision; dizziness; flu symptoms (fever, chills, sore throat); headache; increased heartbeat; increased hunger; joint pain; nervousness; sweating; tiredness; tremor; upper respiratory tract infection.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fever; stomach pain; yellowing of the skin or eyes.

Side Effects by Body System

General

Nateglinide is generally well tolerated with the incidence of adverse effects similar to placebo. Upper respiratory tract infections, dizziness, flu symptoms, arthropathy, and accidental trauma were reported slightly more frequently than placebo in clinical trials.

Musculoskeletal

Musculoskeletal side effects have included back pain (4.0%) and arthropathy (3.3%).

Respiratory

Respiratory side effects have included upper respiratory infection (10.5%), bronchitis (2.7%), and coughing (2.4%).

Endocrine

There were increases in mean uric acid levels for patients treated with nateglinide alone, nateglinide in combination with metformin, metformin alone, and glyburide alone. The respective differences from placebo were 0.29 mg/dL, 0.28 mg/dL, 0.28 mg/dL.

Endocrine side effects have included hypoglycemia (2.4%) and increases in uric acid.

Hypersensitivity

Hypersensitivity side effects have included rare cases of rash, itching and urticaria in postmarketing experience.

Hepatic

Hepatic side effects have included post-marketing reports of jaundice, cholestatic hepatitis, and elevated liver enzymes.

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