Nateglinide Side Effects
It is possible that some side effects of nateglinide may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to nateglinide: oral tablet
As well as its needed effects, nateglinide may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking nateglinide, check with your doctor immediately:Less common
- Convulsions (seizures)
If any of the following side effects occur while taking nateglinide, check with your doctor or nurse as soon as possible:Less common
- Low blood sugar, including anxious feeling, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool pale skin, difficulty in thinking, drowsiness, excessive hunger, fast heartbeat, headache, nausea, nervousness, nightmares, restless sleep, shakiness, slurred speech, or unusual tiredness or weakness
- Hives or welts
- redness of skin
- skin rash
Some nateglinide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common
- runny or stuffy nose
- sore throat
- Abdominal or stomach pain
- back pain
- pain in joints or muscles
- swelling in joints
For Healthcare Professionals
Applies to nateglinide: oral tablet
Nateglinide is generally well tolerated with the incidence of adverse effects similar to placebo. Upper respiratory tract infections, dizziness, flu symptoms, arthropathy, and accidental trauma were reported slightly more frequently than placebo in clinical trials.[Ref]
Musculoskeletal side effects have included back pain (4.0%) and arthropathy (3.3%).[Ref]
Respiratory side effects have included upper respiratory infection (10.5%), bronchitis (2.7%), and coughing (2.4%).[Ref]
There were increases in mean uric acid levels for patients treated with nateglinide alone, nateglinide in combination with metformin, metformin alone, and glyburide alone. The respective differences from placebo were 0.29 mg/dL, 0.28 mg/dL, 0.28 mg/dL.[Ref]
Endocrine side effects have included hypoglycemia (2.4%) and increases in uric acid.[Ref]
Hypersensitivity side effects have included rare cases of rash, itching and urticaria in postmarketing experience.[Ref]
Hepatic side effects have included post-marketing reports of jaundice, cholestatic hepatitis, and elevated liver enzymes.
1. "Product Information. Starlix (nateglinide)" Novartis Pharmaceuticals, East Hanover, NJ.
More about nateglinide
- Other brands: Starlix
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