Nateglinide Side Effects

It is possible that some side effects of nateglinide may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to nateglinide: oral tablet

As well as its needed effects, nateglinide may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking nateglinide, check with your doctor immediately:

Less common
  • Convulsions (seizures)
  • unconsciousness

If any of the following side effects occur while taking nateglinide, check with your doctor or nurse as soon as possible:

Less common
  • Low blood sugar, including anxious feeling, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool pale skin, difficulty in thinking, drowsiness, excessive hunger, fast heartbeat, headache, nausea, nervousness, nightmares, restless sleep, shakiness, slurred speech, or unusual tiredness or weakness
Incidence not known-occurred during clinical practice
  • Hives or welts
  • itching
  • redness of skin
  • skin rash

Some nateglinide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Cough
  • runny or stuffy nose
  • sore throat
Less common
  • Abdominal or stomach pain
  • back pain
  • chills
  • dizziness
  • pain in joints or muscles
  • sneezing
  • swelling in joints

For Healthcare Professionals

Applies to nateglinide: oral tablet

General

Nateglinide is generally well tolerated with the incidence of adverse effects similar to placebo. Upper respiratory tract infections, dizziness, flu symptoms, arthropathy, and accidental trauma were reported slightly more frequently than placebo in clinical trials.

Musculoskeletal

Musculoskeletal side effects have included back pain (4.0%) and arthropathy (3.3%).

Respiratory

Respiratory side effects have included upper respiratory infection (10.5%), bronchitis (2.7%), and coughing (2.4%).

Endocrine

There were increases in mean uric acid levels for patients treated with nateglinide alone, nateglinide in combination with metformin, metformin alone, and glyburide alone. The respective differences from placebo were 0.29 mg/dL, 0.28 mg/dL, 0.28 mg/dL.

Endocrine side effects have included hypoglycemia (2.4%) and increases in uric acid.

Hypersensitivity

Hypersensitivity side effects have included rare cases of rash, itching and urticaria in postmarketing experience.

Hepatic

Hepatic side effects have included post-marketing reports of jaundice, cholestatic hepatitis, and elevated liver enzymes.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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