Nateglinide Side Effects
Some side effects of nateglinide may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to nateglinide: oral tablet
Get emergency medical help if you have any of these signs of an allergic reaction while taking nateglinide: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
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seizure (convulsions); or
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jaundice (yellowing of the skin or eyes).
Less serious side effects of nateglinide may include:
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runny or stuffy nose, sneezing, cough, cold or flu symptoms;
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diarrhea, nausea;
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back pain;
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dizziness; or
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joint pain or stiffness.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to nateglinide: oral tablet
General
Nateglinide is generally well tolerated with the incidence of adverse effects similar to placebo. Upper respiratory tract infections, dizziness, flu symptoms, arthropathy, and accidental trauma were reported slightly more frequently than placebo in clinical trials.
Musculoskeletal
Musculoskeletal side effects have included back pain (4.0%) and arthropathy (3.3%).
Respiratory
Respiratory side effects have included upper respiratory infection (10.5%), bronchitis (2.7%), and coughing (2.4%).
Endocrine
There were increases in mean uric acid levels for patients treated with nateglinide alone, nateglinide in combination with metformin, metformin alone, and glyburide alone. The respective differences from placebo were 0.29 mg/dL, 0.28 mg/dL, 0.28 mg/dL.
Endocrine side effects have included hypoglycemia (2.4%) and increases in uric acid.
Hypersensitivity
Hypersensitivity side effects have included rare cases of rash, itching and urticaria in postmarketing experience.
Hepatic
Hepatic side effects have included post-marketing reports of jaundice, cholestatic hepatitis, and elevated liver enzymes.
More nateglinide resources
- nateglinide Advanced Consumer (Micromedex) - Includes Dosage Information
- nateglinide MedFacts Consumer Leaflet (Wolters Kluwer)
- Nateglinide Prescribing Information (FDA)
- Nateglinide Professional Patient Advice (Wolters Kluwer)
- Nateglinide Monograph (AHFS DI)
- Starlix Prescribing Information (FDA)
- Starlix Consumer Overview
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