Marinol Side Effects

Generic Name: dronabinol

Note: This page contains information about the side effects of dronabinol. Some of the dosage forms included on this document may not apply to the brand name Marinol.

Not all side effects for Marinol may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to dronabinol: oral capsule, oral capsule liquid filled

In addition to its needed effects, some unwanted effects may be caused by dronabinol (the active ingredient contained in Marinol). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking dronabinol:

Less common
  • Changes in mood
  • confusion
  • delusions
  • fast or pounding heartbeat
  • feelings of unreality
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • loss of memory
  • mental depression
  • nervousness or anxiety
  • problems with memory
  • Blurred vision
  • chills
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • sweating
  • unusual tiredness or weakness

If any of the following symptoms of overdose occur while taking dronabinol, get emergency help immediately:

Symptoms of overdose
  • Being forgetful
  • change in how fast you think time is passing
  • change in your sense of smell, taste, sight, sound, or touch
  • constipation
  • decrease in motor coordination
  • drowsiness (severe)
  • dryness of the mouth (severe)
  • false sense of well-being
  • feeling sluggish
  • panic reaction
  • problems in urinating
  • redness of the eyes
  • seizures
  • slurred speech
  • unusual drowsiness or dullness

Some of the side effects that can occur with dronabinol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Clumsiness or unsteadiness
  • dizziness
  • drowsiness
  • false sense of well-being
  • nausea
  • trouble with thinking
  • vomiting
Less common or rare
  • Abdominal or stomach pain
  • flushing of the face
  • lack or loss of strength
  • restlessness
  • Burning, dry, or itching eyes
  • continuing ringing or buzzing or other unexplained noise in the ears
  • cough
  • diarrhea
  • discharge, excessive tearing
  • headache
  • hearing loss
  • redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
  • runny nose
  • sneezing
  • stuffy nose

For Healthcare Professionals

Applies to dronabinol: oral capsule

Nervous system

Nervous system side effects have included amnesia, anxiety/nervousness, ataxia, confusion, depersonalization, dizziness, euphoria, hallucination, paranoid reaction, somnolence, seizure, seizure-like activity, and abnormal thinking.[Ref]


Cardiovascular side effects have included palpitations, tachycardia, and vasodilation/facial flush.[Ref]


Gastrointestinal side effects have included abdominal pain, nausea, and vomiting.[Ref]


General side effects have included asthenia and fatigue.[Ref]


1. Struwe M, Kaempfer SH, Geiger CJ, Pavia AT, Plasse TF, Shepard KV, Ries K, Evans TG "Effect of dronabinol on nutritional status in HIV infection." Ann Pharmacother 27 (1993): 827-31

2. Beal J, Olson R, Shepard KV, Plasse T "Effect of dronabinol on appetite and weight in AIDS: long-term follow- up." Int Conf AIDS 9 (1993): 527(

3. Beal JA "Appetite effect of dronabinol [letter; comment]." J Clin Oncol 12 (1994): 1524-5

4. "Product Information. Marinol (dronabinol)." Roxane Laboratories Inc, Columbus, OH.

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