Megace

Generic Name: megestrol (meh JESS trol)
Brand Names: Megace

What is Megace?

Megace is a man-made chemical similar to the female hormone progesterone.

Megace is used to treat loss of appetite and weight loss because of disease. It is also used in the treatment of advanced breast cancer and endometrial cancer. Exactly how it works to treat loss of appetite and weight loss is unknown.

Megace may also be used for purposes other than those listed in this medication guide.

Important information about Megace

Notify your doctor if you develop any side effects while taking Megace.

Before taking Megace

Before taking Megace, tell your doctor if you have

• diabetes or

• a history of blood clots.

You may not be able to take Megace, or you may require a lower dose or special monitoring during treatment if you have either of the conditions listed above.

Do not take this medication if you are pregnant or are planning a pregnancy. Megestrol is in the FDA pregnancy category X. This means that this medication is known to cause birth defects. Megace may cause abnormal development of the sexual organs. Megace may pass into breast milk and harm a nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take Megace?

Take Megace exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each pill with a full glass of water. Shake the suspension form of Megace well before measuring a dose. To ensure that you get a correct dose, measure the suspension with a dose-measuring spoon or cup, not a regular tablespoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one. Store this medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose, as directed. Do not take a double dose of this medication unless otherwise directed by your doctor.

What happens if I overdose?

A Megace overdose is unlikely to threaten life. Call an emergency room or poison control center for advice.

Symptoms of a Megace overdose are not known.

What should I avoid while taking Megace?

There are no restrictions on food, beverages, or activity during treatment with Megace unless your doctor directs otherwise.

Megace side effects

Stop taking Megace and seek emergency medical attention or call your doctor immediately if you experience any of the following serious side effects:

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• sudden severe headache;

• changes in vision; or

• numbness or swelling in an arm or leg.

Other, less serious side effects may be more likely to occur. Notify your doctor if you experience

• nausea or vomiting,

• dizziness,

• mild shortness of breath;

• weakness,

• headache,

• menstrual bleeding,

• hot flashes or sweating,

• decreased sex drive, or

• insomnia.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Megace?

Before taking Megace, tell your doctor if you are taking insulin or an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase, Glynase), chlorpropamide (Diabinese), tolazamide (Tolinase), or tolbutamide (Orinase). Megace may decrease the effects of these medications, and your blood sugar level may increase. If you have diabetes, monitor your blood sugar and talk to your doctor if you notice any unusual changes.

Drugs other than those listed here may also interact with Megace. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

• Your pharmacist has additional information about Megace written for health professionals that you may read.

What does my medication look like?

Megestrol is available with a prescription generically and under the brand name Megace. Other brand and generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Megace Oral Suspension 40 mg/mL--lemon-lime-flavored suspension

• Megace 20 mg - light-blue, scored tablets

• Megace 40 mg - light-blue, scored tablets

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2008 Cerner Multum, Inc. Version: 2.01. Revision Date: 7/13/05 4:04:46 PM.

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