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Linagliptin Side Effects

Not all side effects for linagliptin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to linagliptin: oral tablet

In addition to its needed effects, some unwanted effects may be caused by linagliptin. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking linagliptin:

More common
  • Anxiety
  • blurred vision
  • chills
  • cold sweats
  • coma
  • confusion
  • cool, pale skin
  • depression
  • dizziness
  • fast heartbeat
  • headache
  • increased hunger
  • nausea
  • nightmares
  • seizures
  • shakiness
  • slurred speech
  • unusual tiredness or weakness
  • Bloating
  • constipation
  • darkened urine
  • fever
  • indigestion
  • loss of appetite
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • vomiting
  • yellow eyes or skin
Incidence not known
  • Flaking and falling off of the skin
  • hives or welts
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • redness of the skin
  • skin rash

Some of the side effects that can occur with linagliptin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Back pain
  • difficulty with moving
  • muscle aches
  • muscle pain or stiffness
  • pain in the joints
  • sore throat
  • stuffy or runny nose
Less common
  • Cough
  • weight gain

For Healthcare Professionals

Applies to linagliptin: oral tablet


Metabolic side effects have included hypoglycemia, hyperlipidemia, hypertriglyceridemia and weight gain.


Hypersensitivity side effects have included urticaria, angioedema, localized skin exfoliation, and bronchial hyperreactivity.


Respiratory side effects have included nasopharyngitis and cough. Side effects reported when linagliptin was used in combination with glimepiride and metformin include upper respiratory infection.


Musculoskeletal side effects have included arthralgia, back pain and myalgia. Side effects reported when linagliptin was used in combination with glimepiride and metformin include pain in extremities.


Endocrine side effects have included pancreatitis.

Nervous system

Nervous system side effects have included headache.


Gastrointestinal side effects reported include diarrhea. Side effects reported when linagliptin was added on to basal insulin therapy include constipation.


Genitourinary side effects reported when linagliptin was used in combination with specific anti-diabetic agents include urinary tract infection.


Increases in uric acid were reported more frequently in patients treated with linagliptin than placebo.

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