Linagliptin Side Effects

Some side effects of linagliptin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to linagliptin: oral tablet

Get emergency medical help if you have any of these signs of an allergic reaction while taking linagliptin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking linagliptin and call your doctor at once if you have a serious side effect such as:

• pancreatitis - severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, fast heart rate; or

• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash.

Less serious side effects of linagliptin may include:

• runny or stuffy nose, sore throat;

• cough;

• weight gain;

• muscle or joint pain;

• headache; or

• back pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to linagliptin: oral tablet

Metabolic

Metabolic side effects have included hypoglycemia, hyperlipidemia, hypertriglyceridemia and weight gain.

Hypersensitivity

Hypersensitivity side effects have included urticaria, angioedema, localized skin exfoliation, and bronchial hyperreactivity.

Respiratory

Respiratory side effects have included nasopharyngitis and cough. Side effects reported when linagliptin was used in combination with glimepiride and metformin include upper respiratory infection.

Musculoskeletal

Musculoskeletal side effects have included arthralgia, back pain and myalgia. Side effects reported when linagliptin was used in combination with glimepiride and metformin include pain in extremities.

Endocrine

Endocrine side effects have included pancreatitis.

Nervous system

Nervous system side effects have included headache.

Gastrointestinal

Gastrointestinal side effects reported include diarrhea. Side effects reported when linagliptin was added on to basal insulin therapy include constipation.

Genitourinary

Genitourinary side effects reported when linagliptin was used in combination with specific anti-diabetic agents include urinary tract infection.

Other

Increases in uric acid were reported more frequently in patients treated with linagliptin than placebo.

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