Librium Side Effects

Generic Name: chlordiazepoxide

Note: This page contains information about the side effects of chlordiazepoxide. Some of the dosage forms included on this document may not apply to the brand name Librium.

Not all side effects for Librium may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to chlordiazepoxide: oral capsule, oral tablet

In addition to its needed effects, some unwanted effects may be caused by chlordiazepoxide (the active ingredient contained in Librium). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking chlordiazepoxide:

  • Fainting
  • mood or mental changes
  • shakiness and unsteady walk
  • unsteadiness, trembling, or other problems with muscle control or coordination
Incidence not known
  • Abdominal and muscle cramps
  • chills
  • clay-colored stools
  • convulsions
  • cough or hoarseness
  • dark urine
  • difficulty in speaking
  • dizziness
  • drooling
  • fever with or without chills
  • general feeling of tiredness or weakness
  • headache
  • itching
  • light-colored stools
  • loss of appetite
  • loss of balance control
  • lower back or side pain
  • muscle trembling, jerking, or stiffness
  • nausea and vomiting
  • painful or difficult urination
  • pale skin
  • rash
  • restlessness
  • shakiness in the legs, arms, hands, or feet
  • shuffling walk
  • sleeplessness
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stiffness of the limbs
  • stomach pain
  • sweating
  • swelling
  • trouble sleeping
  • twisting movements of the body
  • unable to sleep
  • uncontrolled movements, especially of the face, neck, and back
  • unpleasant breath odor
  • unusual bruising or bleeding
  • unusual tiredness or weakness
  • vomiting of blood
  • yellow eyes or skin

If any of the following symptoms of overdose occur while taking chlordiazepoxide, get emergency help immediately:

Symptoms of overdose
  • Change in consciousness
  • lack of coordination
  • loss of consciousness
  • sleepiness or unusual drowsiness

Some of the side effects that can occur with chlordiazepoxide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known
  • Decreased interest in sexual intercourse
  • difficulty having a bowel movement (stool)
  • inability to have or keep an erection
  • increased in sexual ability, desire, drive, or performance
  • increased interest in sexual intercourse
  • loss in sexual ability, desire, drive, or performance
  • menstrual changes
  • skin blisters

For Healthcare Professionals

Applies to chlordiazepoxide: injectable powder for injection, oral capsule, oral tablet

Nervous system

Nervous system side effects are common and most often have included drowsiness, ataxia, and dizziness.

Chlordiazepoxide may impair the psychomotor skills necessary for driving. Persistent electroencephalographic changes (involving a decrease in the mean energy content and an increase in the variability of the EEG) have been reported rarely.


Respiratory side effects have included respiratory depression which may be clinically important in patients with underlying respiratory disease.


Other side effects have included withdrawal symptoms and case reports of hiccups.

Withdrawal symptoms after abrupt cessation of chlordiazepoxide may include agitation, restlessness, anxiety, insomnia, convulsions, tremor, abdominal cramps, vomiting, and sweating.


Psychiatric side effects have included hallucinations, vivid dreaming, agitation, and behavioral disinhibition.


Local side effects have included reactions at the site of parenteral injection (pain, burning, local irritation and swelling).


The manufacturer recommends periodic monitoring of blood counts during protracted treatment with chlordiazepoxide (the active ingredient contained in Librium)

One case of non-thrombocytopenic purpura has also been reported.

Hematologic side effects including blood dyscrasias such as agranulocytosis and thrombocytopenia have been reported rarely.


The manufacturer recommends periodic monitoring of liver function tests during protracted treatment with chlordiazepoxide (the active ingredient contained in Librium)

Hepatic side effects including cholestatic jaundice have been reported rarely. Mild transient increases in liver function tests have also been reported.


Endocrine side effects have included depression of iodine 131 uptake, galactorrhea, and potential aggravation of hyperglycemia in diabetic patients.


Dermatologic side effects have included fixed drug eruptions and drug-induced photosensitivity.


Cardiovascular side effects have rarely included syncope, tachycardia, hypotension, and edema.

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