Chlordiazepoxide Pregnancy and Breastfeeding Warnings

Chlordiazepoxide is also known as: Libritabs, Librium, Mitran

Chlordiazepoxide Pregnancy Warnings

The Collaborative Perinatal Project reported no association between first trimester use of chlordiazepoxide and congenital malformations.

Chlordiazepoxide has not been formally assigned to a pregnancy category by the FDA. Chlordiazepoxide crosses the placenta and achieves a maternal:fetal plasma ratio of 1:1. An increased risk of congenital malformations in humans has been associated with the use of chlordiazepoxide in pregnancy, particularly in the first and second trimesters. Chronic use of chlordiazepoxide in later pregnancy has been associated with neonatal withdrawal and a "floppy infant syndrome" consisting of hypotonia, depression, decreased responsiveness, and reluctance to feed. There are no controlled data in human pregnancy. Chlordiazepoxide should only be given during pregnancy when there are no alternatives and benefit outweighs risk.

Chlordiazepoxide Breastfeeding Warnings

There are no data on the excretion of chlordiazepoxide into human milk.

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