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Iodixanol Side Effects

Not all side effects for iodixanol may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to iodixanol: injection solution

In addition to its needed effects, some unwanted effects may be caused by iodixanol. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking iodixanol, check with your doctor or nurse immediately:

Less common
  • Arm, back, or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • fainting
  • fast or irregular heartbeat
  • nausea
  • shortness of breath
  • sweating
  • Agitation
  • blurred vision
  • chest pain or discomfort
  • coma
  • confusion
  • cough
  • decreased urine output
  • depression
  • difficulty breathing
  • dilated neck veins
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • extreme fatigue
  • fainting
  • feeling of warmth
  • headache
  • hostility
  • irregular breathing
  • irritability
  • lethargy
  • muscle twitching
  • noisy breathing
  • pain or discomfort in the arms, jaw, back, or neck
  • rapid weight gain
  • redness of the face, neck, arms, and occasionally, upper chest
  • seizures
  • severe or sudden headache
  • stupor
  • sudden loss of coordination
  • sudden slurring of speech
  • swelling of the face, ankles, or hands
  • swelling of the fingers, feet, or lower legs
  • vomiting
  • weight gain

Some of the side effects that can occur with iodixanol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Bad, unusual, or unpleasant (after) taste
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in taste
  • diarrhea
  • dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • itching or skin rash
  • sensation of spinning
  • Acid or sour stomach
  • anxiety
  • back pain
  • belching
  • continuing ringing or buzzing or other unexplained noise in the ears
  • decreased awareness or responsiveness
  • dry mouth
  • general feeling of discomfort or illness
  • hearing loss
  • heartburn
  • hives or welts
  • hyperventilation
  • indigestion
  • redness of the skin
  • restlessness
  • severe sleepiness
  • shaking
  • stomach discomfort, upset, or pain
  • transient, mild, pleasant aromatic odor
  • trouble sleeping

For Healthcare Professionals

Applies to iodixanol: injectable solution


Gastrointestinal side effects including nausea (2.8%), vomiting (0.8%), diarrhea (0.6%), and dyspepsia have been reported.


Other side effects including taste perversion (3.5%), parosmia (0.5%), and tinnitus have been reported.

Nervous system

Nervous system side effects including vertigo (2.4%), headache/migraine (2.5%), paresthesia (1.0%), agitation/anxiety/insomnia/nervousness (0.8%), sensory disturbance (0.8%), dizziness (0.7%), syncope (0.6%), cerebral vascular disorder, convulsions, hypoesthesia, stupor, amnesia, and confusion have been reported.[Ref]


Cardiovascular side effects including angina pectoris/chest pain (2.2%), arrhythmias, cardiac failure, conduction abnormalities, hypotension, flushing, peripheral ischemia, cardiac arrest, hypertension, and myocardial infarction have been reported.[Ref]


Dermatologic side effects including non-urticarial rash or erythema (2.1%), pruritus (1.6%), urticaria (0.5%), hematoma, and increased sweating have been reported.[Ref]


Ocular side effects including scotoma (1.1%), cortical blindness, and abnormal vision have been reported.


General side effects including edema (0.6%), back pain, fatigue, and malaise have been reported.[Ref]


Respiratory side effects including asthma, bronchitis, dyspnea, pulmonary edema, pulmonary embolism, respiratory depression, and rhinitis have been reported.


Hypersensitivity side effects including anaphylactoid reactions and pharyngeal edema have been reported.


Musculoskeletal side effects including polymyalgia rheumatica and dyskinesia have been reported.


Renal side effects including abnormal renal function, acute renal failure, and hematuria have been reported.


Metabolic side effects including hypoglycemia have been reported.


Hematologic side effects including hemorrhage have been reported.


1. "Product Information. Visipaque (iodixanol)." Nycomed Inc, Princeton, NJ.

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