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Iodixanol Side Effects

Not all side effects for iodixanol may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to iodixanol: injectable solution

Get emergency medical help if you have any of these signs of an allergic reaction while taking iodixanol: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • swelling, rapid weight gain, little or no urinating;

  • wheezing or trouble breathing;

  • seizure (convulsions);

  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;

  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance; or

  • signs of a blood clot in the lung--chest pain, sudden cough, wheezing, rapid breathing, coughing up blood.

Common side effects may include:

  • pain, warmth, or cold feeling when the medicine was injected;

  • numbness or tingly feeling;

  • dizziness, spinning sensation;

  • chest pain;

  • fever;

  • nausea, vomiting;

  • headache, anxiety, nervousness;

  • skin rash, itching;

  • unusual or unpleasant taste in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to iodixanol: injectable solution


Gastrointestinal side effects including nausea (2.8%), vomiting (0.8%), diarrhea (0.6%), and dyspepsia have been reported.


Other side effects including taste perversion (3.5%), parosmia (0.5%), and tinnitus have been reported.

Nervous system

Nervous system side effects including vertigo (2.4%), headache/migraine (2.5%), paresthesia (1.0%), agitation/anxiety/insomnia/nervousness (0.8%), sensory disturbance (0.8%), dizziness (0.7%), syncope (0.6%), cerebral vascular disorder, convulsions, hypoesthesia, stupor, amnesia, and confusion have been reported.[Ref]


Cardiovascular side effects including angina pectoris/chest pain (2.2%), arrhythmias, cardiac failure, conduction abnormalities, hypotension, flushing, peripheral ischemia, cardiac arrest, hypertension, and myocardial infarction have been reported.[Ref]


Dermatologic side effects including non-urticarial rash or erythema (2.1%), pruritus (1.6%), urticaria (0.5%), hematoma, and increased sweating have been reported.[Ref]


Ocular side effects including scotoma (1.1%), cortical blindness, and abnormal vision have been reported.


General side effects including edema (0.6%), back pain, fatigue, and malaise have been reported.[Ref]


Respiratory side effects including asthma, bronchitis, dyspnea, pulmonary edema, pulmonary embolism, respiratory depression, and rhinitis have been reported.


Hypersensitivity side effects including anaphylactoid reactions and pharyngeal edema have been reported.


Musculoskeletal side effects including polymyalgia rheumatica and dyskinesia have been reported.


Renal side effects including abnormal renal function, acute renal failure, and hematuria have been reported.


Metabolic side effects including hypoglycemia have been reported.


Hematologic side effects including hemorrhage have been reported.


1. "Product Information. Visipaque (iodixanol)." Nycomed Inc, Princeton, NJ.

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