Iodixanol Dosage

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Usual Adult Dose for Intra-arterial Digital Subtraction Angiography

Iodixanol 270 mgI/mL or 320 mgI/mL is recommended for intra-arterial injection for intra-arterial digital subtraction angiography.

Carotid Arteries: 5 to 8 mL (320 mgI/mL)
Vertebral Arteries: 5 to 8 mL (320 mgI/mL)
Max Total Dose: Usually not to exceed 175 mL

Renal Arteries: 10 to 25 mL (270 mgI/mL)
Aortography: 20 to 50 mL (270 mgI/mL), 10 to 50 mL (320 mgI/mL)
Major Branches of Aorta: 5 to 30 mL (270 mgI/mL), 2 to 10 mL (320 mgI/mL)
Aortofemoral Runoffs: 6 to 15 mL (320 mgI/mL)
Peripheral Arteries: 3 to 15 mL (320 mgI/mL)
Max Total Dose: Usually not to exceed 250 mL

Usual Adult Dose for Computed Tomography

Intravenous administration of iodixanol injection (270 mgI/mL or 320 mgI/mL) is recommended for Contrast Enhanced Computed Tomography (CECT).

CECT of Head:
Bolus Infusion:
75 to 150 mL (270 mgI/ mL)
75 to 150 mL (320 mgI/ mL)
Maximum Total Volume: 150 mL

CECT of Body:
Bolus Infusion:
100 to 150 mL (270 mgI/ mL)
100 to 150 mL (320 mgI/ mL)
Maximum Total Volume: 150 mL

Usual Adult Dose for Urography

Intravenous administration of iodixanol injection (270 mgI/mL or 320 mgI/mL) is recommended.

Excretory Urography:
Normal Renal Function:
1 mL/kg (270 mgI/ mL)
1 mL/kg (320 mgI/ mL)
Maximum Total Volume: 100 mL

Usual Adult Dose for Venography

Intravenous administration of iodixanol injection (270 mgI/mL) is recommended.

Venography:
Per Lower Extremity:
50 to 100 mL (270 mgI/ mL)
Maximum Total Volume: 250 mL

Usual Adult Dose for Peripheral Arteriography

Intra-arterial Administration:

Peripheral Arteries: 15 to 30 mL (320 mgI/mL)
Max Total Dose: Usually not to exceed 250 mL

Usual Adult Dose for Cerebral Arteriography

Intra-arterial Administration:

Carotid Arteries: 10 to 14 mL (320 mgI/mL)
Vertebral Arteries: 10 to 12 mL (320 mgI/mL)
Max Total Dose: Usually not to exceed 175 mL

Usual Adult Dose for Coronary Arteriography

Intra-arterial Administration:

Right Coronary Artery 3 to 8 mL (320 mgI/mL)
Left Coronary Artery 3 to 10 mL (320 mgI/mL)
Left Ventricle 20 to 45 mL (320 mgI/mL)
Max Total Dose: Usually not to exceed 200 mL

Usual Adult Dose for Aortography

Intra-arterial Administration:

Aortography: 30 to 70 mL (320 mgI/mL)
Major Branches of Aorta: 10 to 70 mL (320 mgI/mL)
Aortofemoral Runoffs: 20 to 90 mL (320 mgI/mL)
Max Total Dose: Usually not to exceed 250 mL

Usual Adult Dose for Renal Arteriography

Intra-arterial Administration:

Renal Arteries 8 to 18 mL (320 mgI/mL)
Max Total Dose: Usually not to exceed 250 mL

Usual Pediatric Dose for Cerebral Arteriography

Intra-arterial Administration:

Greater than 1 to 12 years of age:

1 to 2 mL/kg (320 mgI/mL)
The total dose should not exceed 4 mL/kg.

Greater than 12 years of age:

Carotid Arteries: 10 to 14 mL (320 mgI/mL)
Vertebral Arteries: 10 to 12 mL (320 mgI/mL)
Max Total Dose: Usually not to exceed 175 mL

Usual Pediatric Dose for Intra-arterial Digital Subtraction Angiography

Iodixanol 270 mgI/mL or 320 mgI/mL is recommended for intra-arterial injection for intra-arterial digital subtraction angiography.

Greater than 12 years of age:

Carotid Arteries: 5 to 8 mL (320 mgI/mL)
Vertebral Arteries: 5 to 8 mL (320 mgI/mL)
Max Total Dose: Usually not to exceed 175 mL

Renal Arteries: 10 to 25 mL (270 mgI/mL)
Aortography: 20 to 50 mL (270 mgI/mL), 10 to 50 mL (320 mgI/mL)
Major Branches of Aorta: 5 to 30 mL (270 mgI/mL), 2 to 10 mL (320 mgI/mL)
Aortofemoral Runoffs: 6 to 15 mL (320 mgI/mL)
Peripheral Arteries: 3 to 15 mL (320 mgI/mL)
Max Total Dose: Usually not to exceed 250 mL

Usual Pediatric Dose for Coronary Arteriography

Intra-arterial Administration:

Greater than 1 to 12 years of age:

1 to 2 mL/kg (320 mgI/mL)
The total dose should not exceed 4 mL/kg.

Greater than 12 years of age:

Right Coronary Artery 3 to 8 mL (320 mgI/mL)
Left Coronary Artery 3 to 10 mL (320 mgI/mL)
Left Ventricle 20 to 45 mL (320 mgI/mL)
Max Total Dose: Usually not to exceed 200 mL

Usual Pediatric Dose for Renal Arteriography

Intra-arterial Administration:

Greater than 12 years of age:

Renal Arteries 8 to 18 mL (320 mgI/mL)
Max Total Dose: Usually not to exceed 250 mL

Usual Pediatric Dose for Aortography

Intra-arterial Administration:

Greater than 1 to 12 years of age:

1 to 2 mL/kg (320 mgI/mL)
The total dose should not exceed 4 mL/kg.

Greater than 12 years of age:

Aortography: 30 to 70 mL (320 mgI/mL)
Major Branches of Aorta: 10 to 70 mL (320 mgI/mL)
Aortofemoral Runoffs: 20 to 90 mL (320 mgI/mL)
Max Total Dose: Usually not to exceed 250 mL

Usual Pediatric Dose for Peripheral Arteriography

Intra-arterial Administration:

Greater than 12 years of age:

Peripheral Arteries: 15 to 30 mL (320 mgI/mL)
Max Total Dose: Usually not to exceed 250 mL

Usual Pediatric Dose for Computed Tomography

Intravenous administration of iodixanol injection (270 mgI/mL or 320 mgI/mL) is recommended for Contrast Enhanced Computed Tomography (CECT).

Greater than 1 to 12 years of age:

1 to 2 mL/kg (270 mgI/mL)
The total dose should not exceed 2 mL/kg.

Greater than 12 years of age:

CECT of Head:
Bolus Infusion:
75 to 150 mL (270 mgI/ mL)
75 to 150 mL (320 mgI/ mL)
Maximum Total Volume: 150 mL

CECT of Body:
Bolus Infusion:
100 to 150 mL (270 mgI/ mL)
100 to 150 mL (320 mgI/ mL)
Maximum Total Volume: 150 mL

Usual Pediatric Dose for Urography

Intravenous administration of iodixanol injection (270 mgI/mL or 320 mgI/mL) is recommended.

Greater than 1 to 12 years of age:

1 to 2 mL/kg (270 mgI/mL)
The total dose should not exceed 2 mL/kg.

Greater than 12 years of age:

Excretory Urography:
Normal Renal Function:
1 mL/kg (270 mgI/ mL)
1 mL/kg (320 mgI/ mL)
Maximum Total Volume: 100 mL

Usual Pediatric Dose for Venography

Intravenous administration of iodixanol injection (270 mgI/mL) is recommended.

Greater than 12 years of age:

Venography:
Per Lower Extremity:
50 to 100 mL (270 mgI/ mL)
Maximum Total Volume: 250 mL

Renal Dose Adjustments

Dose adjustments in patients with renal impairment have not been studied.

Liver Dose Adjustments

Data not available

Dose Adjustments

The combination of volume and concentration of iodixanol injection to be used should be individualized, accounting for factors such as age, body weight, size of the vessel, and rate of blood flow within the vessel. Specific dose adjustment studies for age, gender, weight and renal function have not been conducted with iodixanol. As with other iodinated contrast agents, lower doses may have less risk. The efficacy of iodixanol injection below doses recommended has not been established. Other factors, such as anticipated pathology, degree and extent of opacification required, structure(s) or area to be examined, disease processes affecting the patient, and equipment and technique to be employed, should be considered.

Injection rates should be approximately equal to the flow rate in the vessel being injected. The volume required will depend on the size, flow rate, and disease state of the injected vessel, on the size and condition of the patient, and on the imaging technique used.

Precautions

Iodixanol may be fatal if given intrathecally.

Extravasation should be avoided, especially in patients with severe arterial or venous disease.

In the pediatric population prolonged fasting and the administration of a laxative before iodixanol injection are contraindicated.

The maximum recommended total dose of iodine in adults is 80 grams. The maximum total dose of iodine in the pediatric population has not been established.

If an adverse reaction occurs during injection, consider stopping the injection immediately if warranted by the nature and severity of the event.

Dialysis

Iodixanol has been shown to be dialyzable.

Other Comments

Patients should be adequately hydrated prior to and following the intravascular administration of iodinated contrast agents.

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