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Ibandronate Side Effects

Not all side effects for ibandronate may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to ibandronate: oral tablet

Other dosage forms:

In addition to its needed effects, some unwanted effects may be caused by ibandronate. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking ibandronate:

More common
  • Bladder pain
  • bloody or cloudy urine
  • chest pain
  • cough producing mucus
  • difficult, burning, or painful urination
  • difficulty with breathing
  • fever or chills
  • frequent urge to urinate
  • lower back or side pain
  • nervousness
  • pounding in the ears
  • shortness of breath
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • tightness in the chest
Less common
  • Bloody or cloudy urine
  • body aches or pain
  • congestion
  • difficulty with swallowing
  • dizziness
  • dryness of the throat
  • fast heartbeat
  • frequent urge to urinate
  • hives
  • hoarseness
  • itching
  • numbness
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • runny nose
  • skin rash
  • tender, swollen glands in the neck
  • tingling
  • unusual tiredness or weakness
  • voice changes
Incidence not known
  • Abdominal or stomach cramps
  • blurred vision or other change in vision
  • bone, joint, or muscle pain, severe and occasionally incapacitating
  • confusion
  • convulsions
  • eye redness
  • eye tenderness
  • heavy jaw feeling
  • irregular heartbeats
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loosening of a tooth
  • muscle cramps in the hands, arms, feet, legs, or face
  • noisy breathing
  • numbness and tingling around the mouth, fingertips, or feet
  • pain, swelling, or numbness in the mouth or jaw
  • sensitivity to light
  • severe eye pain
  • tearing
  • tremor
  • unusual pain in the thighs, groin, or hips

If any of the following symptoms of overdose occur while taking ibandronate, get emergency help immediately:

Symptoms of overdose
  • Acid or sour stomach
  • belching
  • bone pain
  • burning feeling in the chest or stomach
  • heartburn
  • indigestion
  • loss of appetite
  • pain or burning in the throat
  • sores or ulcers
  • stomach discomfort, upset, or pain
  • tenderness in the stomach area
  • vomiting
  • white spots on the lips or tongue or inside the mouth

Some of the side effects that can occur with ibandronate may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Diarrhea
  • ear congestion
  • headache
  • loss of voice
  • pain in the extremity (arms and legs)
Less common
  • Cough
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • discouragement
  • feeling of constant movement of self or surroundings
  • feeling sad or empty
  • general feeling of discomfort or illness
  • irritability
  • joint pain
  • lack or loss of strength
  • lightheadedness
  • loss of interest or pleasure
  • muscle aches and pain
  • muscle stiffness
  • pain, swelling, or redness in the joints
  • sensation of spinning
  • shivering
  • stuffy nose
  • sweating
  • tooth disorder
  • trouble concentrating
  • trouble sleeping

For Healthcare Professionals

Applies to ibandronate: intravenous kit, intravenous solution, oral tablet


Gastrointestinal side effects have included nausea, dyspepsia, diarrhea, tooth disorder, vomiting, gastritis, constipation and abdominal pain.[Ref]


Metabolic side effects have included hypercholesterolemia. Hypocalcemia following dosing has been reported postmarketing.[Ref]


Musculoskeletal side effects have included myalgia, joint disorder, back pain, pain in extremities, localized osteoarthritis, muscle cramps and arthritis. Postmarketing side effects have included: severe or incapacitating bone, joint, or muscle pain; osteonecrosis of the jaw; and atypical, low-energy, or low-trauma fracture of the femoral shaft.[Ref]


Cardiovascular side effects have included hypertension.[Ref]

Nervous system

Nervous system side effects have included headache, dizziness, insomnia, vertigo, and nerve root lesion.[Ref]


Respiratory side effects have included upper respiratory tract infection, bronchitis, pneumonia, and pharyngitis. Postmarketing side effects have included exacerbations of asthma.[Ref]


Genitourinary side effects have included urinary tract infection.[Ref]


General side effects have included back pain, infection, asthenia, and influenza-like illness.[Ref]


Dermatologic side effects have included rash.[Ref]


Hypersensitivity side effects have included allergic reactions. Postmarketing side effects have included anaphylactic reaction/shock, and is some cases fatal, angioedema, bronchospasm, asthma exacerbations, and rash have been reported.[Ref]


Ocular side effects have included ocular inflammation such as uveitis and scleritis.[Ref]


Acute renal failure has been reported postmarketing


Psychiatric side effects have included insomnia and depression with intravenous ibandronate.


1. "Product Information. Boniva (ibandronate)." Roche Laboratories, Nutley, NJ.

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