Fluticasone nasal Side Effects
Some side effects of fluticasone nasal may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to fluticasone nasal: nasal spray
Get emergency medical help if you have any of these signs of an allergic reaction while taking fluticasone nasal: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
severe or ongoing nosebleeds;
noisy breathing, runny nose, or crusting around your nostrils;
redness, sores, or white patches in your mouth or throat;
fever, chills, weakness, nausea, vomiting, flu symptoms;
any wound that will not heal; or
blurred vision, eye pain, or seeing halos around lights.
Less serious side effects of fluticasone nasal may include:
headache, back pain;
menstrual problems, loss of interest in sex;
sinus pain, cough, sore throat; or
sores or white patches inside or around your nose.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to fluticasone nasal: nasal spray
Endocrine side effects have included suppression of the hypothalamic-pituitary-adrenal axis. The risk of adrenal suppression is less than that associated with systemic corticosteroids and should be of concern only when using higher than recommended doses. Slight suppression of plasma cortisol has been noted following 250 mcg intranasal doses of fluticasone.
Due to extensive first-pass metabolism of fluticasone to an inactive carboxylic acid, significant systemic effects are not expected from any amount of the drug that may be swallowed via intranasal administration of normally recommended dosages. In one study involving 61 patients, no significant difference was demonstrated in the hypothalamic-pituitary-adrenal axis function among patients given intranasal fluticasone 200 mcg/day or placebo for 1 year.
Local side effects have included nasal irritation including burning, dryness, and soreness in 1% to 6% of patients. Nose bleed has been reported in up to 15% of treated patients and sore throat in 2%. Intranasal fluticasone may also cause sneezing. Nasal ulcerations and Candida albicans infections have been reported. Alteration or loss of sense of taste or smell has been reported rarely. Nasal septal perforation and impaired wound healing has also been reported.
Nervous system adverse effects have included headache in 2% to 4% of patients. Some studies have reported headache in as many as 32% of patients. Dizziness has also been reported.
Gastrointestinal side effects have included nausea, vomiting, and dry mouth.
Hypersensitivity side effects have included postmarketing reports of a systemic eosinophilic condition. Clinical features of this condition have included a vasculitis consistent with Churg-Strauss syndrome, vasculitic rash, worsening pulmonary symptoms, cardiac complications, and/or neuropathy. These events have usually been associated with a reduction and/or discontinuation of oral corticosteroid therapy following introduction of fluticasone.
Rarely, hypersensitivity reactions have been reported including angioedema, rash, face and tongue edema, pruritus, urticaria, bronchospasm, wheezing, dyspnea and anaphylaxis.
Cases of serious eosinophilic conditions also have been reported with other inhaled corticosteroids in this clinical setting.
Ocular side effects have included reports of cataracts and posterior capsular cataracts.
In 1993, the American Academy of Allergy and Immunology (AAAI) requested that the FDA review its decision regarding the labeled risks of the use of inhaled corticosteroids during severe viral infections. The AAAI's request was based on the lack of data linking inhaled corticosteroids to increases in complications of viral infections.
The danger of infections from immune suppression associated with inhaled corticosteroids has been debated. No conclusive evidence is available to support an increase in tuberculosis or viral infections in patients receiving inhaled fluticasone.
Respiratory side effects have included epistaxis, ulcerations, Candida albicans infection, impaired wound healing, and nasal septal perforation.
More fluticasone nasal resources
- Flonase eent Monograph (AHFS DI)
- Flonase Prescribing Information (FDA)
- Flonase Consumer Overview
- Flonase Advanced Consumer (Micromedex) - Includes Dosage Information
- Flonase spray MedFacts Consumer Leaflet (Wolters Kluwer)
- Veramyst Prescribing Information (FDA)
- Veramyst Consumer Overview
- Veramyst spray MedFacts Consumer Leaflet (Wolters Kluwer)
- Veramyst Nasal Advanced Consumer (Micromedex) - Includes Dosage Information
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