Medication Guide App

Cubicin Side Effects

Generic Name: daptomycin

Note: This page contains information about the side effects of daptomycin. Some of the dosage forms included on this document may not apply to the brand name Cubicin.

Not all side effects for Cubicin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to daptomycin: intravenous powder for solution

In addition to its needed effects, some unwanted effects may be caused by daptomycin (the active ingredient contained in Cubicin). In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking daptomycin, check with your doctor or nurse immediately:

More common
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • fever
  • rapid weight gain
  • tingling of the hands or feet
  • unusual weight gain or loss
Less common
  • Abdominal or stomach pain
  • agitation
  • black, tarry stools
  • bladder pain
  • bloody or cloudy urine
  • blurred vision
  • chest pain or discomfort
  • chills
  • coma
  • confusion
  • convulsions
  • cough
  • decreased frequency or amount of urine
  • decreased urine output
  • depression
  • diarrhea
  • difficult or labored breathing
  • difficult, burning, or painful urination
  • dilated neck veins
  • dizziness
  • dry mouth
  • extreme fatigue
  • fainting
  • faintness or lightheadedness when getting up suddenly from a lying or sitting position
  • fast heartbeat
  • frequent urge to urinate
  • headache
  • hostility
  • increased blood pressure
  • increased thirst
  • irregular breathing
  • irregular heartbeat
  • irritability
  • itching in the genital or other skin areas
  • itching, pain, redness, swelling, tenderness, or warmth on the skin
  • lethargy
  • lightheadedness
  • loss of appetite
  • lower back or side pain
  • mood changes
  • muscle pain or cramps
  • muscle twitching
  • nausea
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • pale skin
  • pounding in the ears
  • rapid weight gain
  • rapid, shallow breathing
  • scaling
  • seizures
  • shortness of breath
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • stupor
  • sweating
  • swelling of the face, fingers, ankles, or hands
  • tightness in the chest
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • usual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds
  • weight gain
  • wheezing
  • Bleeding gums
  • blood in the urine or stools
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • clay-colored stools
  • dark urine
  • difficulty with moving
  • drowsiness
  • eye pain
  • feeling of warmth
  • feeling unusually cold
  • general feeling of illness
  • headache
  • hives
  • hoarseness
  • increase in bone pain
  • irritation
  • itching
  • joint pain, stiffness, or swelling
  • loss of appetite
  • mood or mental changes
  • muscle aching or cramping
  • muscle spasms (tetany) or twitching
  • no blood pressure or pulse
  • pain in the joints
  • pinpoint red spots on the skin
  • rapid or irregular heartbeat
  • rash
  • redness of the face, neck, arms, and occasionally, upper chest
  • redness of the skin
  • redness, blistering, peeling, or loosening of the skin
  • shivering
  • skin rash, encrusted, scaly and oozing
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stopping of heart
  • swelling of the eyelids, face, lips, hands, or feet
  • swollen glands
  • swollen joints
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • trembling
  • troubled breathing or swallowing
  • twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
  • unconsciousness
  • unpleasant breath odor
  • unusual bleeding or bruising
  • vomiting of blood
  • yellow eyes or skin
Incidence not known
  • Abdominal or stomach cramps
  • abdominal or stomach tenderness
  • diarrhea, watery and severe, which may also be bloody
  • difficulty with swallowing
  • dry cough
  • pain
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • unusual weight loss

Some of the side effects that can occur with daptomycin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • diarrhea, mild
  • difficulty having a bowel movement (stool)
Less common
  • Anxiety
  • back pain
  • blurred vision
  • cold sweats
  • coma
  • cool, pale skin
  • decreased appetite
  • depression
  • flushed, dry skin
  • fruit-like breath odor
  • increased hunger
  • increased urination
  • itching of the vagina or outside genitals
  • lack or loss of strength
  • limb pain
  • nervousness
  • nightmares
  • pain during sexual intercourse
  • shakiness
  • skin rash
  • sleeplessness
  • slurred speech
  • sweating
  • thick, white, curd-like vaginal discharge without odor or with mild odor
  • trouble sleeping
  • unable to sleep
  • unexplained weight loss
  • Acid or sour stomach
  • bad, unusual, or unpleasant (after) taste
  • belching
  • change in taste
  • continuing ringing or buzzing or other unexplained noise in the ears
  • excess air or gas in the stomach or intestines
  • feeling of constant movement of self or surroundings
  • full feeling
  • hearing loss
  • heartburn
  • indigestion
  • pain or discomfort in the chest, upper stomach, or throat
  • passing gas
  • pressure in the stomach
  • red, sore eyes
  • seeing, hearing, or feeling things that are not there
  • sensation of spinning
  • sore mouth or tongue
  • swelling of the abdominal or stomach area
  • swelling or inflammation of the mouth
  • weakness
  • white patches in the mouth or on the tongue

For Healthcare Professionals

Applies to daptomycin: intravenous powder for injection


In Phase 3 complicated skin and skin structure infection trials, daptomycin (the active ingredient contained in Cubicin) was discontinued in 2.8% of patients due to a side effect, while comparator was discontinued in 3% of patients. In the Staphylococcus aureus bacteremia/endocarditis trial, daptomycin was discontinued in 16.7% of patients due to a side effect, while comparator was discontinued in 18.1% of patients.

In Phase 3 community-acquired pneumonia trials, the death rate and rates of serious cardiorespiratory side effects were higher with daptomycin than comparator due to lack of therapeutic efficacy.[Ref]


In clinical studies, 0.2% of patients had symptoms of muscle pain or weakness associated with CPK elevations to greater than 4 times ULN. After discontinuation of daptomycin (the active ingredient contained in Cubicin) CPK returned to normal within 7 to 10 days and symptoms resolved within 3 days.

A 45-year-old female with refractory acute myeloid leukemia was admitted to the blood and marrow transplant unit for a second attempt to induce remission with myeloablative chemotherapy of high-dose cytarabine. Two months prior, the patient's first course of induction therapy was complicated by neutropenic fever and vancomycin- resistant Enterococcus faecium (VRE) bacteremia that was treated with linezolid for 14 days. The patient was also receiving aztreonam, levofloxacin, acyclovir, amphotericin B lipid complex, and azithromycin. Once her clinical status stabilized, she was transferred from the intensive care unit (ICU) back to the blood and marrow transplant unit. After receiving 8 of 12 scheduled doses of cytarabine, the patient required readmission to the medical ICU due to a decrease in mental status, supraventricular tachycardia, and hypotension. Cultures of blood and urine samples at the time of her transfer showed VRE with intermediate resistance to linezolid. The patient, who was neutropenic at this time, was started on IV daptomycin 550 mg (6 mg/kg) every 24 hours. The patient's baseline CPK was 108 units/L and serum creatinine level was 0.8 mg/dL. Over the following 7 days, the patient's CPK level gradually increased, and on day 10 of daptomycin therapy, her CPK level was 996 units/L, blood urea nitrogen level (BUN) was 73 mg/dL, and serum creatinine level was 1.9 mg/dL. To evaluate for rhabdomyolysis, urine myoglobin was measured and reported at 30,890 ng/mL. Rhabdomyolysis was diagnosed based on increased CPK and urine myoglobin level in a patient with acute renal failure. Daptomycin was discontinued and the patient was started on treatment for rhabdomyolysis. Despite aggressive hydration and diuresis, CPK and urine myoglobin levels continued to increase up to 5350 units/L and 47,166 ng/mL, respectively. Over 2 weeks, the patient's CPK and urine myoglobin levels slowly resolved. The final CPK and urine myoglobin levels measured were 3395 units/L and 451 ng/mL, respectively.

In another case, a 53-year-old African-American female with a history of hypertension, diabetes mellitus, and peripheral vascular disease was admitted to the hospital and an MRI revealed L5-S1 discitis and osteomyelitis. After an 8-week course of empirical antibiotic therapy with vancomycin and levofloxacin, an open biopsy was performed. Specimens from the biopsy cultured positive for Torulopsis glabrata, VRE, and methicillin-resistant S aureus (MRSA) and the patient was started on daptomycin 360 mg (6 mg/kg) IV as a single daily dose and voriconazole 250 mg twice daily. Ten days after the start of daptomycin therapy, the patient developed generalized muscular weakness that progressed to the point she was unable to get out of bed. The patient then developed nonoliguric acute renal failure with a serum creatinine of 27 mg/mL up from baseline of 9 mg/mL. A CPK level drawn was elevated to 21,243 units/L and was associated with elevated levels aspartate aminotransferase (AST) 375 units/L, alanine aminotransferase (ALT) 219 units/L, and lactate dehydrogenase (LDH) 666 units/L. Urinalysis was positive for hemoglobin, myoglobin, and red blood cells which conferred a diagnosis of acute renal failure secondary to daptomycin-induced rhabdomyolysis. After daptomycin was discontinued and IV fluid was administered to alkalinize the urine, renal function, CPK, and liver function tests returned to baseline as well as dissipation of muscular weakness. Myoglobin, hemoglobin, and the red blood cells disappeared from urine as well.

In another similar case, a 52-year-old male with a history hepatitis C, IV drug abuse, idiopathic thrombocytopenia, and hyperlipidemia was admitted to the hospital and an MRI revealed findings compatible with L3-L4 discitis and osteomyelitis. He was started on vancomycin but it was discontinued after a rash developed. Daptomycin was started at 500 mg (6.5 mg/kg) IV as a single daily dose. The patient was also on simvastatin; however, it was discontinued prior to initiation of daptomycin therapy. After nine days into the course of daptomycin therapy, the patient developed generalized muscle weakness progressing to the point where he was unable to get out of bed. The patient's CPK rose to 20,771 units/L from a baseline of 102 units/L. AST 239 units/L and ALT 40 units/L were elevated from baseline and alkaline phosphatase was elevated to 118 units/L. Daptomycin was discontinued and the patient was admitted to the ICU for close monitoring and hydration. The patient slowly improved and recovered all muscle strength and within 2 weeks his enzymes returned to baseline.[Ref]

Common (1% to 10%): Elevated creatine phosphokinase (CPK; up to 9.3%)
Uncommon (0.1% to 1%): Myalgia (less than 1%), muscle cramps (less than 1%), muscle weakness (less than 1%), arthralgia (less than 1%), symptoms of muscle pain or weakness associated with CPK elevations to greater than 4 times upper limit of normal (ULN)
Frequency not reported: Pain in extremity, limb pain, back pain, myositis, osteomyelitis, muscle twitching, myopathy (with minor increases in CPK), rhabdomyolysis (with secondary acute renal failure), severe myopathy (with possible hepatotoxicity)
Postmarketing reports: Increased myoglobin, rhabdomyolysis (some cases involved concurrent use of daptomycin and HMG-CoA reductase inhibitors)[Ref]


Common (1% to 10%): Insomnia (9%)
Uncommon (0.1% to 1%): Mental status change (less than 1%)
Frequency not reported: Anxiety, hallucination, confusion[Ref]


Common (1% to 10%): Serious Gram-negative infections (including bloodstream infections, cholangitis, alcoholic pancreatitis, sternal osteomyelitis/mediastinitis, bowel infarction, recurrent Crohn's disease, recurrent line sepsis, recurrent urosepsis; 8.3%), chest pain (7%), edema (7%), sepsis (5%), bacteremia (5%)
Uncommon (0.1% to 1%): Fatigue (less than 1%), weakness (less than 1%), rigors (less than 1%), flushing (less than 1%), taste disturbance (less than 1%)
Frequency not reported: Discomfort, jitteriness, pneumonia, fungal infections, candidal infection, fungemia, fever, chapped lips, peripheral edema, adenoviral upper respiratory infection, upper respiratory tract infection (not otherwise specified)[Ref]

Serious Gram-negative infections (including bloodstream infections) were reported in 10/120 daptomycin-treated patients in the S aureus bacteremia/endocarditis trial compared to 0/115 in comparator-treated patients. Gram-negative infections included cholangitis, alcoholic pancreatitis, sternal osteomyelitis/mediastinitis, bowel infarction, recurrent Crohn's disease, recurrent line sepsis, and recurrent urosepsis.

One patient developed S aureus endocarditis with a 2 cm mitral vegetation, bowel infarction, and polymicrobial bacteremia that ultimately lead to death following mitral valve repair complicated by sternal osteomyelitis.[Ref]


Common (1% to 10%): Pharyngolaryngeal pain (8%), dyspnea (2.1%)
Frequency not reported: Pleural effusions, sore throat
Postmarketing reports: Cough, eosinophilic pneumonia[Ref]

Symptoms of eosinophilic pneumonia have included fever, dyspnea with hypoxic respiratory insufficiency, diffuse pulmonary infiltrates, cough, shortness of breath, and difficulty breathing. Eosinophilic pneumonia may lead to progressive respiratory failure and is potentially fatal if not quickly recognized and appropriately managed.[Ref]


Common (1% to 10%): Abdominal pain (6%), diarrhea (5.2%)
Uncommon (0.1% to 1%): Abdominal distention (less than 1%), stomatitis (less than 1%)
Frequency not reported: Dry mouth, epigastric discomfort, gingival pain, oral candidiasis, oral hypoesthesia, constipation, dyspepsia, flatulence, loose stools, gastrointestinal hemorrhage, abnormal bowel sounds, aphthous stomatitis
Postmarketing reports: Clostridium difficile associated diarrhea, nausea, vomiting[Ref]


Common (1% to 10%): Pruritus (6%), increased sweating (5%), rash (4.3%)
Uncommon (0.1% to 1%): Eczema (less than 1%)
Frequency not reported: Heat rash, generalized pruritus, vesicular rash, erythema, cellulitis, papular rash
Postmarketing reports: Serious skin reactions (including Stevens-Johnson syndrome, vesiculobullous rash [with or without mucous membrane involvement])[Ref]


Common (1% to 10%): Hypertension (6%), hypotension (2.4%)
Uncommon (0.1% to 1%): Supraventricular arrhythmia (less than 1%)
Frequency not reported: Atrial fibrillation, atrial flutter, cardiac arrest, cardiac failure, cardiac disorders (unspecified)[Ref]

Nervous system

Common (1% to 10%): Headache (5.4%), dizziness (2.2%)
Uncommon (0.1% to 1%): Vertigo (less than 1%), paresthesia (less than 1%)
Frequency not reported: Peripheral nervous system events (such as paresthesias, dysesthesias, peripheral neuropathies), tinnitus, dyskinesia
Postmarketing reports: Peripheral neuropathy[Ref]


Common (1% to 10%): Abnormal liver function tests (up to 3%)
Uncommon (0.1% to 1%): Jaundice (less than 1%), increased serum lactate dehydrogenase (less than 1%)
Rare (less than 0.1%): Hepatobiliary disorder (at least 1 case)
Frequency not reported: Increased alanine aminotransferase, increased aspartate aminotransferase[Ref]


Common (1% to 10%): Urinary tract infections (2.4%)
Frequency not reported: Vaginal candidiasis, fungal urinary tract infection, proteinuria, vaginal discharge, asymptomatic foamy urine[Ref]


Uncommon (0.1% to 1%): Leukocytosis (less than 1%), thrombocytopenia (less than 1%), thrombocytosis (less than 1%), eosinophilia (less than 1%), increased INR (less than 1%)
Frequency not reported: Lymphadenopathy, thrombocythemia, prolonged prothrombin time, anemia[Ref]


Uncommon (0.1% to 1%): Hypomagnesemia (less than 1%), increased serum bicarbonate (less than 1%), electrolyte disturbance (less than 1%)
Frequency not reported: Increased blood phosphorous, elevated alkaline phosphatase, decreased appetite, hypoglycemia, hypokalemia, hyperkalemia[Ref]


Uncommon (0.1% to 1%): Hypersensitivity (less than 1%)
Postmarketing reports: Anaphylaxis, hypersensitivity reactions (including angioedema, drug rash with eosinophilia and systemic symptoms [DRESS], pruritus, hives, shortness of breath, difficulty swallowing, truncal erythema, pulmonary eosinophilia)[Ref]


Uncommon (0.1% to 1%): Eye irritation (less than 1%)
Frequency not reported: Blurred vision[Ref]


Frequency not reported: Renal impairment (including interstitial nephritis, toxic nephropathy, acute prerenal failure, acute or chronic renal failure, renal impairment, renal tubular necrosis), worsening CrCl/decreased renal function, renal failure, acute renal failure[Ref]


Frequency not reported: Injection site reactions, injection site erythema, injection site phlebitis[Ref]


Frequency not reported: Benign and malignant neoplasms (unspecified)[Ref]


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2. Doan TL, Depetrillo J, Singer C "Daptomycin-induced eosinophilia without pulmonary involvement." Am J Health Syst Pharm 67 (2010): 2107-9

3. Veligandla SR, Louie KR, Malesker MA, Smith PW "Muscle pain associated with daptomycin." Ann Pharmacother 38 (2004): 1860-2

4. Abraham G, Finkelberg D, Spooner LM "Daptomycin-induced acute renal and hepatic toxicity without rhabdomyolysis (May)." Ann Pharmacother 42 (2008): 719-21

5. Kazory A, Dibadj K, Weiner ID "Rhabdomyolysis and acute renal failure in a patient treated with daptomycin." J Antimicrob Chemother (2006):

6. Akins RL, Haase MR, Levy EN "Pharmacokinetics of daptomycin in a critically ill adolescent with vancomycin-resistant enterococcal endocarditis." Pharmacotherapy 26 (2006): 694-8

7. Hawkey PM "Pre-clinical experience with daptomycin." J Antimicrob Chemother 62 Suppl 3 (2008): iii7-14

8. Deryke CA, Sutherland C, Zhang B, Nicolau DP, Kuti JL "Serum Bactericidal Activities of High-Dose Daptomycin with and without Coadministration of Gentamicin against Isolates of Staphylococcus aureus and Enterococcus species." Antimicrob Agents Chemother 50 (2006): 3529-34

9. Papadopoulos S, Ball AM, Liewer SE, Martin CA, Winstead PS, Murphy BS "Rhabdomyolysis during therapy with daptomycin." Clin Infect Dis 42 (2006): e108-10

10. Raghavan M, Linden PK "Newer treatment options for skin and soft tissue infections." Drugs 64 (2004): 1621-42

11. Echevarria K, Datta P, Cadena J, Lewis JS 2nd "Severe myopathy and possible hepatotoxicity related to daptomycin." J Antimicrob Chemother 55 (2005): 599-600

12. Grayson ML "The treatment triangle for staphylococcal infections." N Engl J Med 355 (2006): 724-7

13. Fowler VG Jr, Boucher HW, Corey GR, et al. "Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureus." N Engl J Med 355 (2006): 653-65

14. Cobb E, Kimbrough RC, Nugent KM, Phy MP "Organizing pneumonia and pulmonary eosinophilic infiltration associated with daptomycin." Ann Pharmacother 41 (2007): 696-701

15. Miller BA, Gray A, Leblanc TW, Sexton DJ, Martin AR, Slama TG "Acute eosinophilic pneumonia secondary to daptomycin: a report of three cases." Clin Infect Dis 50 (2010): e63-8

16. Lal Y, Assimacopoulos AP "Two cases of daptomycin-induced eosinophilic pneumonia and chronic pneumonitis." Clin Infect Dis 50 (2010): 737-40

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