Daptomycin use while Breastfeeding
Drugs containing Daptomycin: Cubicin
Daptomycin Levels and Effects while Breastfeeding
Summary of Use during Lactation
Limited information indicates that daptomycin produces low levels in milk and it would not be expected to cause any adverse effects in breastfed infants. No special precautions are required.
Drug Levels
Maternal Levels. A nursing mother received intravenous daptomycin 500 mg (6.7 mg/kg) and ertapenem 1 gram once daily for 28 days to treat a pelvic infection. On day 27 of therapy, expressed breastmilk was collected over six 4-hour intervals. Daptomycin milk concentrations were highest in the second sample with a concentration of 44.7 mcg/L. The fifth sample, ending at 20 hours after the dose, contained 29.2 mcg/L of daptomycin and the final sample had no detectable drug (<25 mcg/L).[1]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Possible Effects on Lactation
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
References
1. Buitrago MI, Crompton JA, Bertolami S et al. Extremely low excretion of daptomycin into breast milk of a nursing mother with methicillin-resistant Staphylococcus aureus pelvic inflammatory disease. Pharmacotherapy. 2009;29:347-51. PMID: 19249952
Daptomycin Identification
Substance Name
CAS Registry Number
103060-53-3
Drug Class
- Antiinfective Agents
- Antibacterial Agents
- Peptides, Cyclic
- Lipopeptides
Administrative Information
LactMed Record Number
708
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
2010-02-12
Disclaimer
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
See Also...
- Daptomycin use during Pregnancy
- Daptomycin Consumer Information
- Breastfeeding Support Group
- Safe Medications during Breastfeeding
- Medicine use while Breastfeeding
- Medicine use during Pregnancy
Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.
