Daptomycin Pregnancy and Breastfeeding Warnings

Daptomycin is also known as: Cubicin

Daptomycin Pregnancy Warnings

Daptomycin has been assigned to pregnancy category B by the FDA. Animal studies have failed to reveal evidence of fetal harm. There are no controlled data in human pregnancy. Daptomycin is only recommended for use during pregnancy when benefit outweighs risk.

Daptomycin Breastfeeding Warnings

In one case study, 6.7 mg/kg/day of intravenous daptomycin was administered to a nursing mother for 28 days. Samples of the patient's breast milk were collected over a 24-hour period on day 27. The highest daptomycin level measured in the breast milk was 0.045 mcg/mL. The calculated maximum daily daptomycin dose to the infant (assuming mean milk consumption of 150 mL/kg/day) was 0.1% of the maternal dose.

Daptomycin is excreted into human milk; however, it has poor oral bioavailability. The effects in the nursing infant are unknown. The manufacturer recommends that caution be used when administering daptomycin to nursing women.

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