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Brinzolamide ophthalmic Side Effects

Not all side effects for brinzolamide ophthalmic may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to brinzolamide ophthalmic: ophthalmic suspension

In addition to its needed effects, some unwanted effects may be caused by brinzolamide ophthalmic. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking brinzolamide ophthalmic:

More common
  • Blurred vision
Less common
  • Discharge from the eye
  • dry eyes
  • redness, soreness, irritation, or pain of the eye or eyelid
  • skin rash
  • Chest pain
  • cough
  • crusting in the corner of the eye
  • difficulty with swallowing
  • dizziness
  • double vision
  • excessive muscle tone
  • eye redness, irritation, or pain
  • fast heartbeat
  • hives
  • itching, swelling, or other signs of eye or eyelid irritation
  • kidney pain
  • muscle stiffness
  • muscle tension or tightness
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • seeing double
  • shortness of breath
  • sore throat
  • tightness in the chest
  • unusual tiredness or weakness
  • wheezing
Incidence not known
  • Abdominal or stomach pain
  • blistering, peeling, or loosening of the skin
  • chills
  • clay-colored stools
  • dark urine
  • diarrhea
  • fever with or without chills
  • general feeling of tiredness or weakness
  • headache
  • hoarseness
  • joint or muscle pain
  • loss of appetite
  • lower back or side pain
  • nausea
  • painful or difficult urination
  • red or irritated eyes
  • red skin lesions, often with a purple center
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen or painful glands
  • unpleasant breath odor
  • unusual bleeding or bruising
  • vomiting of blood
  • yellow eyes or skin

If any of the following symptoms of overdose occur while taking brinzolamide ophthalmic, get emergency help immediately:

Symptoms of overdose
  • Confusion
  • irregular heartbeat
  • muscle cramps or pain
  • numbness, tingling, pain, or weakness in the hands or feet
  • seizures
  • trembling
  • weakness and heaviness of the legs

Some of the side effects that can occur with brinzolamide ophthalmic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Bitter, sour, or other unusual taste
Less common
  • Burning, stinging, or discomfort when medicine is applied
  • dry eyes
  • feeling of something in the eye
  • runny nose
  • sneezing
  • stuffy nose
  • Acid or sour stomach
  • belching
  • body aches or pain
  • congestion
  • difficult or labored breathing
  • dry mouth
  • hair loss
  • heartburn
  • hives or welts
  • indigestion
  • stomach discomfort, upset, or pain
  • tender, swollen glands in the neck
  • thinning of the hair
  • voice changes

For Healthcare Professionals

Applies to brinzolamide ophthalmic: ophthalmic suspension


Common (1% to 10%): Blepharitis, dry eye, foreign body sensation, ocular hyperemia, ocular discharge, ocular discomfort, ocular keratitis, ocular pain, ocular pruritus, blurred vision, eye irritation
Uncommon (0.1% to 1%): Conjunctivitis, diplopia, eye fatigue, keratoconjunctivitis, lid margin crusting or sticky sensation, tearing, corneal erosion, punctate keratitis, keratopathy, corneal staining, corneal epithelium defect, corneal epithelium disorder, increased intraocular pressure, increased optic nerve cup/disc ratio, corneal edema, eye swelling, meibomianitis, glare, photophobia, photopsia, reduced visual acuity, allergic conjunctivitis, pterygium, scleral pigmentation, asthenopia, keratoconjunctivitis sicca, eye hypoesthesia, subconjunctival cyst, conjunctival hyperemia, eyelids pruritus
Frequency not reported: Corneal disorder, visual disturbance, eye allergy, madarosis, eyelid disorder, eyelid erythema[Ref]


Common (1% to 10%): Allergic reactions
Frequency not reported: Hypersensitivity[Ref]


Uncommon (0.1% to 1%): Pain, asthenia, fatigue, feeling abnormal, feeling jittery
Frequency not reported: Peripheral edema, malaise, medication residue[Ref]

Nervous system

Common (1% to 10%): Headache, dysgeusia, tinnitus
Uncommon (0.1% to 1%): Dizziness, hypertonia, somnolence, motor dysfunction, amnesia, memory impairment, paresthesia
Frequency not reported: Tremor, hypoesthesia, ageusia, vertigo[Ref]


Common (1% to 10%): Dermatitis
Uncommon (0.1% to 1%): Alopecia, urticaria, rash, maculo-papular rash, generalized pruritus, skin tightness[Ref]


Uncommon (0.1% to 1%): Diarrhea, dry mouth, dyspepsia, nausea, esophagitis, vomiting, upper abdominal pain, abdominal discomfort, stomach discomfort, flatulence, frequent bowel movements, gastrointestinal disorder, oral hypoesthesia, oral paresthesia[Ref]


Common (1% to 10%): Rhinitis
Uncommon (0.1% to 1%): Dyspnea, pharyngitis, nasopharyngitis, sinusitis, bronchial hyperactivity, cough, epistaxis, pharyngolaryngeal pain, throat irritation, nasal congestion, upper respiratory tract congestion, postnasal drip, rhinorrhea, sneezing, nasal dryness
Frequency not reported: Asthma[Ref]


Uncommon (0.1% to 1%): Cardio-respiratory distress, angina pectoris, bradycardia, irregular palpitations
Frequency not reported: Arrhythmia, tachycardia, hypertension, increased blood pressure, increased heart rate[Ref]


Uncommon (0.1% to 1%): Back pain, muscle spasms, myalgia
Frequency not reported: Arthralgia, pain in extremity[Ref]


Uncommon (0.1% to 1%): Kidney pain
Frequency not reported: Pollakiuria[Ref]


The most commonly reported adverse reactions were blurred vision and bitter, sour or unusual taste.[Ref]


Uncommon (0.1% to 1%): Decreased libido, erectile dysfunction[Ref]


Uncommon (0.1% to 1%): Decreased red blood cell count, increased blood chloride[Ref]


Frequency not reported: Abnormal liver function test[Ref]


Uncommon (0.1% to 1%): Apathy, depression, depressed mood, nightmare, insomnia, nervousness, irritability[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Azopt (brinzolamide ophthalmic)." Alcon Laboratories Inc, Fort Worth, TX.

3. Cerner Multum, Inc. "Australian Product Information." O 0

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