Adderall XR Side Effects

Generic Name: amphetamine / dextroamphetamine

Note: This page contains information about the side effects of amphetamine / dextroamphetamine. Some of the dosage forms included on this document may not apply to the brand name Adderall XR.

Not all side effects for Adderall XR may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to amphetamine / dextroamphetamine: oral capsule extended release, oral tablet

In addition to its needed effects, some unwanted effects may be caused by amphetamine / dextroamphetamine. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking amphetamine / dextroamphetamine:

More common
  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • fast, pounding, or irregular heartbeat or pulse
  • frequent urge to urinate
  • lower back or side pain
Less common
  • Cold or flu-like symptoms
  • cough or hoarseness
  • fever or chills
Incidence not known
  • Blistering, peeling, or loosening of the skin
  • chest pain or discomfort
  • confusion
  • convulsions
  • diarrhea
  • difficulty breathing
  • difficulty with speaking
  • difficulty with swallowing
  • dizziness
  • double vision
  • faintness
  • headache
  • inability to move the arms, legs, or facial muscles
  • inability to speak
  • itching
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of bladder control
  • muscle spasm or jerking of all extremities
  • nausea
  • pain or discomfort in the arms, jaw, back, or neck
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • seeing, hearing, or feeling things that are not there
  • skin rash
  • slow speech
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • sudden loss of consciousness
  • sweating
  • swelling of the feet or lower legs
  • tightness in the chest
  • troubled breathing
  • uncontrolled repeated movements (tics)
  • uncontrolled vocal outbursts
  • unusual tiredness or weakness
  • vomiting
  • wheezing

Some of the side effects that can occur with amphetamine / dextroamphetamine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Anxiety
  • dry mouth
  • lack or loss of strength
  • stomach pain
  • weight loss
Incidence not known
  • Constipation
  • decreased interest in sexual intercourse
  • false or unusual sense of well-being
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs

For Healthcare Professionals

Applies to amphetamine / dextroamphetamine: oral capsule extended release, oral tablet

Gastrointestinal

Gastrointestinal side effects have included dry mouth (35%), loss of appetite (33%), nausea (8%), diarrhea (6%), unpleasant taste, constipation, (undesired) anorexia, weight loss, and other disturbances.

Nervous system

Nervous system side effects have included insomnia (27%), agitation (8%), anxiety (8%), dizziness (7%), depression, seizures, stroke, overstimulation, restlessness, euphoria, dyskinesia, dysphoria, tremor, headache, exacerbation of motor and phonic tics, and Tourette's syndrome. Additional reports have included irritability, aggression, anger, logorrhea, dermatillomania and paresthesia (including formication).

It is unclear whether CNS stimulant drugs (i.e., dextroamphetamine, methylphenidate, amphetamine-dextroamphetamine) have a role in either the development or worsening of tic disorders such as Tourette's syndrome. According to several case reports, use of CNS stimulant medications may have precipitated or exacerbated tic disorders in some patients with ADHD. Based on these cases, in Tourette's-susceptible patients, CNS stimulants may exacerbate motor and phonic tics that do not subside following discontinuation of the offending agent. In several controlled studies involving patients with ADHD and tic disorders, in the majority of patients, tics did not increase following use of CNS stimulants. In addition, controlled studies have not found that methylphenidate worsens motor tics in Tourette's syndrome nor has it increased tics in patients without Tourette's. However, it should be noted that tics were reported in 7% of patients using the methylphenidate patch compared to 1% to those taking it orally. Additional studies are required in order to clarify this association.

Metabolic

Metabolic side effects including weight loss (11%) have been reported.

Cardiovascular

Cardiovascular side effects have included tachycardia (6%), palpitations, elevated blood pressure, sudden death, and myocardial infarction. There are isolated reports of cardiomyopathy associated with chronic amphetamine use.

Genitourinary

Genitourinary side effects including urinary tract infection (5%), dysmenorrhea, changes in libido, frequent or prolonged erections and impotence have been reported.

Other

Other side effects have included a significant elevation (highest in the evening) of the plasma corticosteroid levels. Amphetamines may interfere with urinary steroid determination. Headache (26%), asthenia (6%), somnolence, infection, tooth disorder, speech disorder, and twitching have also been reported.

Dermatologic

Dermatologic side effects have included urticaria, photosensitivity reaction, and sweating. Additional reports have included alopecia.

Endocrine

Endocrine side effects have included impotence and changes in libido.

Psychiatric

Psychiatric side effects including emotional lability and psychotic episodes have been reported rarely at recommended doses.

Respiratory

Respiratory side effects including dyspnea have been reported.

Hypersensitivity

Hypersensitivity side effects have included urticaria rash, angioedema and anaphylaxis, Stevens-Johnson Syndrome and toxic epidermal necrolysis.

Ocular

Ocular side effects have included blurred vision and mydriasis.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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