How does Ocrevus work for MS?
Ocrevus (ocrelizumab) works in multiple sclerosis (MS) by targeting a specific protein, called CD20 that exists on the surface of immature and mature B-lymphocytes. B lymphocytes are a type of white blood cell which are thought to contribute to the development of MS in several different ways, including secreting antibodies during an MS attack that cause inflammation which damages the myelin coating around nerve cells in the brain and spinal cord. When Ocrevus binds to this protein, it causes B-cells to self-destruct or disintegrate.
Ocrevus is a targeted treatment that is approved for the treatment of relapsing forms of multiple sclerosis (MS) and primary progressive MS in adults. It is a biological treatment called a monoclonal antibody.
How effective is Ocrevus in MS?
Research has shown that Ocrevus is effective at reducing the number of relapses per year in people with MS, increasing the percentage of people who remain relapse-free, and reducing the rate of disability progression. In one trial in people with early primary progressive MS, people taking Ocrevus were 24% less likely to have an increase in their disability than those taking placebo, which equates to delaying the need for a wheelchair by approximately seven years.
Ocrevus is given as an intravenous infusion every six months, after an initial dose of two infusions two weeks apart.
References
- Ocrevus (ocrelizumab) 05/2020 Genentech, Inc. https://www.drugs.com/pro/ocrevus.html
- Ocrevus. National Multiple Sclerosis Society. 2020 https://www.nationalmssociety.org/Treating-MS/Medications/Ocrevus#:~:text=Ocrevus%20is%20approved%20by%20the,primary%20progressive%20MS%20in%20adults.
- Lehmann-Horn K, Kronsbein HC, Weber MS. Targeting B cells in the treatment of multiple sclerosis: recent advances and remaining challenges. Ther Adv Neurol Disord. 2013;6(3):161-173. DOI:10.1177/1756285612474333
Read next
Related medical questions
- How long does it take Ocrevus to work?
- Is Ocrevus a form of chemotherapy?
- How long does an Ocrevus infusion take?
- What types of MS does Ocrevus treat?
- What are the new drugs used for multiple sclerosis (MS)?
- Ocrevus vs Aubagio: How do they compare for MS?
- How long can you live with multiple sclerosis?
- What are the early warning signs of Multiple Sclerosis?
- How do you test for multiple sclerosis?
- What are the early signs of multiple sclerosis?
- Prednisone: What are 12 Things You Should Know?
- Prednisone vs Prednisolone - What's the difference?
- Who is the actress in the Kesimpta commercial?
- Is Tecfidera an immunosuppressant?
- How do Vumerity and Tecfidera compare for multiple sclerosis (MS)?
- Can I stop taking Tecfidera? What happens if I do?
- What causes flushing with Tecfidera?
- Can you drink alcohol while taking Tecfidera?
- Where and how should Copaxone be injected?
- Does Tysabri suppress the immune system?
- How effective is Mavenclad for MS?
- How long can you take Tysabri for?
- Gilenya vs Tecfidera. How do they compare?
- How long can you take Tecfidera?
- What happens when you stop taking Gilenya?
- How quickly does Mavenclad work?
- Does Aubagio suppress the immune system?
- Can Gilenya cause weight gain?
- Is Mavenclad a chemotherapy drug?
- Can Tecfidera cause stomach damage?
Drug information
Related support groups
- Ocrevus (12 questions, 12 members)
- Ocrelizumab (7 questions, 3 members)
- Multiple Sclerosis (89 questions, 549 members)