Azole antifungals

A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Azole antifungals are a group of fungistatic agents with broad-spectrum activity. They are classified into two groups: the triazoles and the imidazoles.

The azole antifungals inhibit the cytochrome P450 dependent enzyme lanosterol 14-alpha-demethylase, which coverts lanosterol to ergosterol, the main sterol in fungal cell membrane. Depletion of ergosterol damages the cell membrane resulting in cell death.

Azole antifungal agents can be used to treat systemic and topical (athletes foot, ringworm, etc.) fungal infections .

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