Azole antifungals
What are Azole antifungals?
Azole antifungals are a group of medicines that contain an azole ring and inhibit the growth of a wide range of fungi. They are classified into two groups: those with two nitrogens in the azole ring (the imidazoles; examples include clotrimazole, econazole, ketoconazole, miconazole, and tioconazole) and those with three nitrogens in the azole ring (the triazoles; examples include fluconazole, itraconazole, posaconazole, and voriconazole).
Azole antifungals work by inhibiting the cytochrome P450 dependent enzyme lanosterol 14-alpha-demethylase, which converts lanosterol to ergosterol, the main sterol in the fungal cell membrane. Depletion of ergosterol damages the cell membrane resulting in cell death.
Azole antifungal agents can be used to treat fungal infections of the body and skin, including athlete's foot, onychomycosis (fungal nail infections), ringworm, and vaginal candidiasis.
List of Azole antifungals
| Drug Name | Avg. Rating | Reviews |
|---|---|---|
| miconazole systemic Brand name: Oravig | No reviews | |
| oteseconazole systemic (Pro) Brand name: Vivjoa | No reviews | |
| clotrimazole systemic (Pro) Brand name: Mycelex Troche |
45 reviews | |
| isavuconazonium systemic (Pro) Brand name: Cresemba |
3 reviews | |
| voriconazole systemic (Pro) Brand name: Vfend |
7 reviews | |
| fluconazole systemic (Pro) Brand name: Diflucan |
530 reviews | |
| ketoconazole systemic (Pro) |
24 reviews | |
| itraconazole systemic (Pro) Brand names: Sporanox, Tolsura |
53 reviews | |
| posaconazole systemic (Pro) Brand name: Noxafil |
2 reviews | |
| For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective). | ||
See also
Medical conditions treated or associated with azole antifungals:
- Aspergillosis, Aspergilloma
- Aspergillosis, Invasive
- Blastomycosis
- Bone Marrow Transplantation
- Candida Urinary Tract Infection
- Candidemia
- Chromomycosis
- Chronic Mucocutaneous Candidiasis
- Coccidioidomycosis
- Coccidioidomycosis, Meningitis
- Cryptococcal Meningitis, Immunocompetent Host
- Cryptococcal Meningitis, Immunosuppressed Host
- Cryptococcosis
- Cutaneous Fungal Infection
- Dermatophytosis
- Esophageal Candidiasis
- Eumycetoma
- Febrile Neutropenia
- Fungal Infection Prevention
- Fungal Infection Prophylaxis
- Fungal Infection, Internal and Disseminated
- Fungal Meningitis
- Fungal Peritonitis
- Fungal Pneumonia
- Fusariosis
- Histoplasmosis
- Microsporidiosis
- Mucormycosis, Invasive
- Ocular Fungal Infection
- Onychomycosis, Fingernail
- Onychomycosis, Toenail
- Oral Thrush
- Paracoccidioidomycosis
- Pseudoallescheriosis
- Sporotrichosis
- Systemic Candidiasis
- Systemic Fungal Infection
- Tinea Capitis
- Tinea Versicolor
- Vaginal Yeast Infection
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.