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Propofol Dosage

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Usual Adult Dose for:

Usual Geriatric Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Anesthesia

Less than 55 years: Anesthetic Induction: 40 mg IV every 10 seconds until induction onset. Total dose required is 2 to 2.5 mg/kg with a maximum of 250 mg.

Less than 55 years: Maintenance of Anesthesia: IV infusion: 100 to 200 mcg/kg/min. Maximum dose 20,000 mcg/min. Maximum dose 10,000 mcg/min.
Intermittent bolus: 20 to 50 mg as needed.

Cardiac Anesthesia: Induction: 20 mg every 10 seconds until induction onset (0.5 to 1.5 mg/kg).
Maintenance: Opioids are generally combined with propofol for maintenance of anesthesia.
100 to 150 mcg/kg/min (primary propofol)
50 to 100 mcg/kg/min (secondary propofol).
Maximum dose of 15,000 mcg/min.

Neurosurgery: Induction: 20 mg every 10 seconds until induction onset (1 to 2 mg/kg).
Maintenance: 100 to 200 mcg/kg/min with a maximum dose of 20,000 mcg/min.
Intermittent IV bolus doses of 0.3 to 0.7 mg/kg mg may be given for maintenance of anesthesia while on nitrous oxide.

ICU Sedation: Initial Continuous IV: 5 mcg/kg/min for intubated mechanically ventilated patients.
Maintenance Continuous IV: May increase in 5 to 10 mcg/kg/min increments every 5 minutes until the desired level of sedation is achieved. Typical maintenance range is 5 to 50 mcg/kg/min.
Bolus administration of 10 to 20 mg should only be used to rapidly increase depth of sedation in patients where hypotension is not likely to occur.

MAC sedation: Initial Continuous IV: 100 to 150 mcg/kg/min for 3 to 5 minutes or
Slow IV: 0.5 mg/kg over 3 to 5 minutes followed by:
Maintenance IV infusion: 25 to 75 mcg/kg/min (preferred) or
incremental bolus doses of 10 to 20 mg.

Usual Geriatric Dose for Anesthesia

Elderly, debilitated, or ASA III/IV patients.
Induction: 20 mg every 10 seconds until induction onset (1-1.5 mg/kg). Maximum dose 200 mg
Maintenance: 50-100 mcg/kg/min.
MAC sedation: The maintenance dose is usually 80% of the usual adult dose.

Usual Pediatric Dose for Anesthesia

3 years to 16 years: Induction: 2.5 to 3.5 mg/kg over 20 to 30 seconds.
Maintenance: 125 to 300 mcg/kg/min.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Higher infusion rates (150 to 200 mcg/kg/min) are often required during the initial maintenance phase following induction. Infusion rates should subsequently be decreased 30% to 50% during the first 30 minutes of maintenance.

Precautions

Dosage and rate of administration should be individualized and titrated to the desired effect, according to clinically relevant factors, including preinduction and concomitant medications, age, ASA physical classification, and level of debilitation of the patient.

Due to a shortage, the FDA is allowing the US market to be supplied with an international product labeled as Fresenius Propoven 1% (propofol 1%). This product does not contain an anti-microbial retardant. After being drawn up into a syringe, the syringe should be discarded after 6 hours. The unused portion of a vial should be discarded immediately following vial penetration. Discard all product and infusion therapy systems after 12 hours.

Fresenius Propoven contains a combination of medium-chain triglycerides (MCT) plus long-chain triglycerides (LCT). The presence of MCTs should be taken into consideration when treating patients with disorders of fat metabolism or who are receiving TPN.

Fresenius Propoven is contraindicated in patients who are allergic to soy or peanut.

Dialysis

Data not available

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