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Fingolimod Dosage

Medically reviewed by Drugs.com. Last updated on Jun 22, 2023.

Applies to the following strengths: 0.5 mg; 0.25 mg

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Multiple Sclerosis

0.5 mg orally once a day

Comments:


Use: For relapsing forms of multiple sclerosis (MS)

Usual Pediatric Dose for Multiple Sclerosis

10 years and older and weighing 40 kg or less:
0.25 mg orally once a day

10 years and older and weighing more than 40 kg:
0.5 mg orally once a day

Comments:


Use: For relapsing forms of multiple sclerosis (MS) in patients 10 years and older

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Mild to moderate hepatic impairment: No adjustment recommended.
Severe hepatic impairment: Closely monitor patients.

Dose Adjustments


FIRST 6 HOUR MONITORING:
Administer the first dose in a setting with resources to manage symptomatic bradycardia. Monitor all patients for 6 hours after the first dose for bradycardia with hourly pulse and blood pressure measurement.

ADDITIONAL MONITORING AFTER 6-HOUR MONITORING:
1) The heart rate 6 hours post dose is less than 45 beats per minute (BPM) in adults, less than 55 BPM in pediatric patients 12 years and older, or less than 60 BPM in pediatric patients 10 or 11 years of age.
2) The heart rate 6 hours post dose is at the lowest value post dose suggesting that the maximum pharmacodynamic effect on the heart may not have occurred.
3) The ECG 6 hours post dose shows new onset second degree or higher atrioventricular (AV) block.
treatment is required, continue monitoring overnight and repeat 6-hour monitoring after the second dose.

OVERNIGHT MONITORING:
Continuous overnight ECG monitoring in a medical facility should be instituted:

MONITORING AFTER REINITIATION OF THERAPY FOLLOWING DISCONTINUATION:

Precautions

CONTRAINDICATIONS:


Safety and efficacy have not been established in patients younger than 10 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Storage requirements:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.