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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Anxiety
Moderate anxiety: 5 to 10 mg orally 3 to 4 times a day.
Severe anxiety: 20 to 25 mg orally 3 to 4 times a day or 50 to 100 mg IM or IV followed by 25 to 50 mg 3 to 4 times a day if necessary.
Usual Adult Dose for Light Sedation
For light sedation prior to a medical or surgical procedure.
Oral: 5 mg 3 times a day may be started several days before the procedure.
IM: 50 mg one hour before the procedure
Usual Adult Dose for Alcohol Withdrawal
IM or IV: 50 to 100 mg initially. May repeat in 2 to 4 hours if necessary.
Oral: 50 to 100 mg followed by repeated doses as needed until agitation is controlled (up to 300 mg/day).
Dosage should then be reduced to maintenance levels.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Should be used with caution in patients with renal or hepatic impairment.
Chlordiazepoxide should not be discontinued abruptly in patients who have received the medication for long periods. Abrupt discontinuation may result in symptoms of withdrawal.
Because of the possibility of respiratory depression, equipment for resuscitation should be immediately available when chlordiazepoxide must be given by a parenteral route.
Because chlordiazepoxide has a long half-life in elderly patients producing prolonged sedation and increasing the risk of falls and fractures, chlordiazepoxide meets the Beers criteria as a medication that is potentially inappropriate for use in older adults. Short- or intermediate-acting benzodiazepines are preferable if a benzodiazepine is required. A large prospective cohort study found that among benzodiazepines and independent of half-life, higher doses of flurazepam, chlordiazepoxide, and oxazepam are associated with the greatest risk of injury (e.g., fall- related fracture or laceration) in the elderly. The authors suggest that these benzodiazepines should be avoided in the elderly, particularly at higher doses.
Chlordiazepoxide is not dialyzable.
In most cases, acute symptoms may be rapidly controlled by parenteral administration so that subsequent treatment, if necessary, may be given orally.
Maximum dosage: 300 mg during a 6 hour period (not recommended in children <12 years old).
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