Chlordiazepoxide Side Effects
Some side effects of chlordiazepoxide may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to chlordiazepoxide: oral capsule, oral tablet
Along with its needed effects, chlordiazepoxide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking chlordiazepoxide:Rare
- mood or mental changes
- shakiness and unsteady walk
- unsteadiness, trembling, or other problems with muscle control or coordination
- Abdominal and muscle cramps
- clay-colored stools
- cough or hoarseness
- dark urine
- difficulty in speaking
- fever with or without chills
- general feeling of tiredness or weakness
- light-colored stools
- loss of appetite
- loss of balance control
- lower back or side pain
- muscle trembling, jerking, or stiffness
- nausea and vomiting
- painful or difficult urination
- pale skin
- shakiness in the legs, arms, hands, or feet
- shuffling walk
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- stiffness of the limbs
- stomach pain
- trouble sleeping
- twisting movements of the body
- unable to sleep
- uncontrolled movements, especially of the face, neck, and back
- unpleasant breath odor
- unusual bruising or bleeding
- unusual tiredness or weakness
- vomiting of blood
- yellow eyes or skin
Get emergency help immediately if any of the following symptoms of overdose occur while taking chlordiazepoxide:Symptoms of overdose
- Change in consciousness
- lack of coordination
- loss of consciousness
- sleepiness or unusual drowsiness
Some side effects of chlordiazepoxide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Incidence not known
- Decreased interest in sexual intercourse
- difficulty having a bowel movement (stool)
- inability to have or keep an erection
- increased in sexual ability, desire, drive, or performance
- increased interest in sexual intercourse
- loss in sexual ability, desire, drive, or performance
- menstrual changes
- skin blisters
For Healthcare Professionals
Applies to chlordiazepoxide: injectable powder for injection, oral capsule, oral tablet
Nervous system side effects are common and most often have included drowsiness, ataxia, and dizziness.
Chlordiazepoxide may impair the psychomotor skills necessary for driving. Persistent electroencephalographic changes (involving a decrease in the mean energy content and an increase in the variability of the EEG) have been reported rarely.
Respiratory side effects have included respiratory depression which may be clinically important in patients with underlying respiratory disease.
Other side effects have included withdrawal symptoms and case reports of hiccups.
Withdrawal symptoms after abrupt cessation of chlordiazepoxide may include agitation, restlessness, anxiety, insomnia, convulsions, tremor, abdominal cramps, vomiting, and sweating.
Psychiatric side effects have included hallucinations, vivid dreaming, agitation, and behavioral disinhibition.
Local side effects have included reactions at the site of parenteral injection (pain, burning, local irritation and swelling).
The manufacturer recommends periodic monitoring of blood counts during protracted treatment with chlordiazepoxide.
One case of non-thrombocytopenic purpura has also been reported.
Hematologic side effects including blood dyscrasias such as agranulocytosis and thrombocytopenia have been reported rarely.
Hepatic side effects including cholestatic jaundice have been reported rarely. Mild transient increases in liver function tests have also been reported.
The manufacturer recommends periodic monitoring of liver function tests during protracted treatment with chlordiazepoxide.
Endocrine side effects have included depression of iodine 131 uptake, galactorrhea, and potential aggravation of hyperglycemia in diabetic patients.
Dermatologic side effects have included fixed drug eruptions and drug-induced photosensitivity.
Cardiovascular side effects have rarely included syncope, tachycardia, hypotension, and edema.
More chlordiazepoxide resources
- chlordiazepoxide MedFacts Consumer Leaflet (Wolters Kluwer)
- chlordiazepoxide Concise Consumer Information (Cerner Multum)
- chlordiazepoxide Advanced Consumer (Micromedex) - Includes Dosage Information
- Chlordiazepoxide Prescribing Information (FDA)
- Chlordiazepoxide Professional Patient Advice (Wolters Kluwer)
- Chlordiazepoxide Monograph (AHFS DI)
- Librium Prescribing Information (FDA)
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