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Fesoterodine Disease Interactions

There are 6 disease interactions with fesoterodine.

Major

Fesoterodine (applies to fesoterodine) GI retention

Major Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Obstruction

The use of fesoterodine is contraindicated in patients with gastric retention. Fesoterodine is a competitive muscarinic receptor antagonist and exerts direct antispasmodic effects on smooth muscles. Caution is advised even when using this agent in patients with decreased gastrointestinal motility.

References

  1. "Product Information. Toviaz (fesoterodine)." Pfizer U.S. Pharmaceuticals Group (2008):
Major

Fesoterodine (applies to fesoterodine) narrow-angle glaucoma

Major Potential Hazard, Moderate plausibility. Applicable conditions: Glaucoma (Narrow Angle)

The use of fesoterodine is contraindicated in patients with uncontrolled narrow-angle glaucoma. Fesoterodine is a competitive muscarinic receptor antagonist. Its use can result in increased intraocular pressure and loss of accommodation. Caution is advised even when using this agent in patients being treated for narrow-angle glaucoma.

References

  1. "Product Information. Toviaz (fesoterodine)." Pfizer U.S. Pharmaceuticals Group (2008):
Major

Fesoterodine (applies to fesoterodine) urinary retention

Major Potential Hazard, Moderate plausibility.

The use of fesoterodine is contraindicated in patients with urinary retention. Fesoterodine is a competitive muscarinic receptor antagonist and exerts direct antispasmodic effects on smooth muscles. Caution is advised even when using this agent in patients with clinically significant bladder outlet obstruction because of the risk of urinary retention.

References

  1. "Product Information. Toviaz (fesoterodine)." Pfizer U.S. Pharmaceuticals Group (2008):
Moderate

Fesoterodine (applies to fesoterodine) hepatic dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

The use of fesoterodine has not been studied in patients with severe hepatic impairment and therefore is not recommended for use in this patient population. No dose adjustment is recommended in patients with mild or moderate hepatic impairment. Use caution when using this agent in patients with severe hepatic impairment.

References

  1. "Product Information. Toviaz (fesoterodine)." Pfizer U.S. Pharmaceuticals Group (2008):
Moderate

Fesoterodine (applies to fesoterodine) myasthenia gravis

Moderate Potential Hazard, Moderate plausibility.

Fesoterodine is a competitive muscarinic receptor antagonist. Fesoterodine should be used with caution in patients with myasthenia gravis, a disease characterized by decreased cholinergic activity at the neuromuscular junction.

References

  1. "Product Information. Toviaz (fesoterodine)." Pfizer U.S. Pharmaceuticals Group (2008):
Moderate

Fesoterodine (applies to fesoterodine) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

Doses of fesoterodine fumarate greater than 4 mg are not recommended in patients with severe renal impairment. No dose adjustment is recommended in patients with mild or moderate renal impairment.

References

  1. "Product Information. Toviaz (fesoterodine)." Pfizer U.S. Pharmaceuticals Group (2008):

Fesoterodine drug interactions

There are 305 drug interactions with fesoterodine.

Fesoterodine alcohol/food interactions

There is 1 alcohol/food interaction with fesoterodine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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