Fesoterodine Dosage

This dosage information may not include all the information needed to use Fesoterodine safely and effectively. See additional information for Fesoterodine.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Urinary Incontinence

Initial dose: 4 mg orally once daily

Maintenance dose: The dose may be increased to 8 mg orally once daily based upon individual response and tolerability.

Usual Adult Dose for Urinary Frequency

Initial dose: 4 mg orally once daily

Maintenance dose: The dose may be increased to 8 mg orally once daily based upon individual response and tolerability.

Renal Dose Adjustments

CrCl 30 mL/min or more: No adjustment recommended.

CrCl less than 30 mL/min: The daily dose should not exceed 4 mg.

Liver Dose Adjustments

Mild to moderate hepatic impairment: No adjustment recommended.

Severe hepatic impairment (Child-Pugh C): Use is not recommended.

Dose Adjustments

The total daily dose of fesoterodine should not exceed 4 mg in the presence of potent CYP450 3A4 inhibitors such as ketoconazole, itraconazole, and clarithromycin. In patients taking weak or moderate CYP450 3A4 inhibitors (e.g., erythromycin), careful assessment of tolerability at the 4 mg daily dose is advised prior to increasing the daily dose to 8 mg. The manufacturer does not recommend any dosage adjustments of fesoterodine when given with CYP450 2D6 inhibitors or CYP450 3A4 inducers.

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

Other Comments

Fesoterodine should be taken with liquid and swallowed whole, not chewed, divided, or crushed. It can be administered with or without food.

In clinical studies, no overall differences in safety or effectiveness were observed between patients younger than 65 years of age and those older than 65. However, the incidence of antimuscarinic adverse events, including dry mouth, constipation, dyspepsia, increase in residual urine, dizziness (at 8 mg only) and urinary tract infection, was higher in patients 75 years of age and older as compared to younger patients.

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