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Trihexyphenidyl

Pronunciation

Generic Name: trihexyphenidyl (try-hex-ee-FEN-i-dill)
Brand Name: Generic only. No brands available.

Trihexyphenidyl is used for:

Treating Parkinson disease and other Parkinson-like disorders when used in combination with other medicines. It is used to treat Parkinson-like side effects (eg, involuntary movements) of certain medicines. It may also be used for other conditions as determined by your doctor.

Trihexyphenidyl is an anticholinergic. It works by blocking certain nerve impulses and relaxing certain muscles.

Do NOT use trihexyphenidyl if:

  • you are allergic to any ingredient in trihexyphenidyl
  • you have angle-closure glaucoma, narrowing of the esophagus, stomach or bowel problems (eg, blockage, ulcerative colitis), heart problems due to bleeding, myasthenia gravis, or urinary blockage

Contact your doctor or health care provider right away if any of these apply to you.

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Before using trihexyphenidyl:

Some medical conditions may interact with trihexyphenidyl. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have high blood pressure, liver or kidney problems, heart problems (eg, irregular heartbeat), blood vessel problems (eg, narrowing), prostate problems, or difficulty urinating
  • if you have a history of involuntary movements of the face, tongue, lips, trunk, or extremities
  • if you have open-angle glaucoma or you are at risk for glaucoma

Some MEDICINES MAY INTERACT with trihexyphenidyl. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Phenothiazines (eg, chlorpromazine) because their effectiveness may be decreased or toxic effects increased by trihexyphenidyl

This may not be a complete list of all interactions that may occur. Ask your health care provider if trihexyphenidyl may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use trihexyphenidyl:

Use trihexyphenidyl as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take trihexyphenidyl by mouth before or after meals.
  • If trihexyphenidyl tends to dry your mouth excessively, it may be better to take it before meals, unless it causes nausea. If taken after meals, thirst can be improved by sucking hard sugarless candy, chewing gum, or drinking water.
  • If you miss a dose of trihexyphenidyl, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use trihexyphenidyl.

Important safety information:

  • Trihexyphenidyl may cause dizziness, drowsiness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use trihexyphenidyl with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Trihexyphenidyl may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Do not become overheated in hot weather or while you are being active; heatstroke may occur.
  • Lab tests, including eye exams, may be performed while you use trihexyphenidyl. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use trihexyphenidyl with caution in the ELDERLY, especially patients who may be constipated; they may be more sensitive to its effects.
  • Trihexyphenidyl should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using trihexyphenidyl while you are pregnant. It is not known if trihexyphenidyl is found in breast milk. If you are or will be breast-feeding while you use trihexyphenidyl, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of trihexyphenidyl:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; constipation; dizziness; drowsiness; dry mouth; headache; increased sensitivity of the eyes to light; lightheadedness; loss of appetite; nausea; nervousness; trembling of the hands; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; chest pain; confusion; delusions; difficult swallowing; difficult urination; facial pain or swelling; fast or pounding heartbeat; fever or chills; hallucinations; mood or mental changes; severe constipation; swollen throat glands; uncontrolled movements.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include depression; difficulty breathing; dilated or sluggish pupils; dry skin; fast breathing; fast heartbeat; high blood pressure; hot, dry, flushed skin.

Proper storage of trihexyphenidyl:

Store trihexyphenidyl at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tight, light-resistant container. Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep trihexyphenidyl out of the reach of children and away from pets.

General information:

  • If you have any questions about trihexyphenidyl, please talk with your doctor, pharmacist, or other health care provider.
  • Trihexyphenidyl is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take trihexyphenidyl or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about trihexyphenidyl. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to trihexyphenidyl. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using trihexyphenidyl.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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