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Pentoxifylline

Pronunciation

Generic Name: pentoxifylline (PEN-tox-IF-i-lin)
Brand Name: Trental

Pentoxifylline is used for:

Treating intermittent claudication in certain patients to reduce pain, cramping, numbness, or weakness in the arms or legs. It may also be used for other conditions as determined by your doctor.

Pentoxifylline is a xanthine derivative. It works by making red blood cells more flexible, which helps to improve blood flow.

Do NOT use pentoxifylline if:

  • you are allergic to any ingredient in pentoxifylline or to methylxanthines (eg, theophylline, caffeine, theobromine)
  • you have had recent bleeding in the brain or eye

Contact your doctor or health care provider right away if any of these apply to you.

Before using pentoxifylline:

Some medical conditions may interact with pentoxifylline. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have stomach or bowel ulcers, blood vessel problems (eg, in the heart or brain), heart problems (eg, chest pain, irregular heartbeat), high or low blood pressure, kidney problems, or a history of bleeding in the brain or eye
  • if you have recently had surgery
  • if you take medicine for high blood pressure

Some MEDICINES MAY INTERACT with pentoxifylline. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin) or antiplatelet medicines (eg, clopidogrel) because the risk of bleeding may be increased
  • Theophylline because the risk of its side effects may be increased by pentoxifylline

This may not be a complete list of all interactions that may occur. Ask your health care provider if pentoxifylline may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use pentoxifylline:

Use pentoxifylline as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take pentoxifylline by mouth with a meal.
  • Swallow pentoxifylline whole. Do not break, crush, or chew before swallowing.
  • Continue to take pentoxifylline even if you feel well. Do not miss any doses.
  • If you miss a dose of pentoxifylline, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use pentoxifylline.

Important safety information:

  • Pentoxifylline may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use pentoxifylline with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Tell your doctor or dentist that you take pentoxifylline before you receive any medical or dental care, emergency care, or surgery.
  • It may take 2 to 4 weeks to notice improvement in your condition, and up to 8 weeks for maximum relief. Do NOT take more than the recommended dose, change your dose, or take pentoxifylline for longer than prescribed without checking with your doctor.
  • Pentoxifylline should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using pentoxifylline while you are pregnant. Pentoxifylline is found in breast milk. Do not breast-feed while taking pentoxifylline.

Possible side effects of pentoxifylline:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Belching; bloating; dizziness; flushing; gas; indigestion; nausea; stomach discomfort or upset; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; chest pain; fainting; irregular heartbeat; severe or persistent dizziness or light-headedness; stomach pain; unusual bruising or bleeding; unusual tiredness or weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; drowsiness; fainting; fever; flushing; loss of consciousness; seizures; severe dizziness.

Proper storage of pentoxifylline:

Store pentoxifylline at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep pentoxifylline out of the reach of children and away from pets.

General information:

  • If you have any questions about pentoxifylline, please talk with your doctor, pharmacist, or other health care provider.
  • Pentoxifylline is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take pentoxifylline or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about pentoxifylline. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to pentoxifylline. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using pentoxifylline.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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