Skip to Content

Generic Name: cilostazol (sye LOE sta zol)
Brand Name: Pletal

What is Pletal (cilostazol)?

Cilostazol is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). Cilostazol dilates arteries that supply blood to your legs. Cilostazol also improves circulation by keeping platelets in the blood from sticking together and clotting.

Cilostazol is used to treat the symptoms of intermittent claudication. This condition causes reduced blood flow to the legs, leading to pain while walking. Cilostazol improves your ability to walk longer distances without pain.

Cilostazol may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Pletal (cilostazol)?

Do not take cilostazol if you have congestive heart failure.

Slideshow: 11 Signs of Alzheimer's Disease - Or Are You Just Getting Older?

What should I discuss with my healthcare provider before taking Pletal (cilostazol)?

Do not take cilostazol if you have congestive heart failure. Cilostazol can make this condition worse.

To make sure cilostazol is safe for you, tell your doctor if you have:

  • kidney disease;

  • liver disease;

  • heart disease; or

  • if you smoke.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether cilostazol passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How should I take Pletal (cilostazol)?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Cilostazol is usually taken twice a day on an empty stomach, at least 30 minutes before or 2 hours after breakfast or dinner.

Take the medicine at the same time each day.

It may take up to 12 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 4 weeks of treatment.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Pletal (cilostazol)?

Grapefruit and grapefruit juice may interact with cilostazol and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.

Pletal (cilostazol) side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • chest pain, pounding heartbeats or fluttering in your chest;

  • a light-headed feeling, like you might pass out;

  • fever, chills, body aches, flu symptoms;

  • bloody urine, painful urination;

  • shortness of breath, even with mild exertion; or

  • swelling of your ankles or feet.

Common side effects may include:

  • headache, dizziness;

  • diarrhea, abnormal bowel movements;

  • upset stomach; or

  • runny nose.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Pletal (cilostazol)?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • aprepitant;

  • imatinib;

  • isoniazid;

  • omeprazole (Prilosec) or esomeprazole (Nexium);

  • ticlopidine;

  • an antidepressant--fluoxetine, fluvoxamine, nefazodone;

  • an antibiotic--clarithromycin, ciprofloxacin, erythromycin, telithromycin;

  • antifungal medicine--fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole;

  • heart medication--diltiazem, nicardipine, quinidine, verapamil; or

  • antiviral medicine to treat hepatitis C or HIV/AIDS--atazanavir, boceprevir, cobicistat, darunavir (when given with ritonavir), delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, telaprevir.

This list is not complete. Other drugs may interact with cilostazol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about cilostazol.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 4.01. Revision Date: 2015-04-09, 9:39:56 AM.

(web3)