Pentoxifylline use while Breastfeeding
Drugs containing Pentoxifylline: Trental, Pentoxil
Pentoxifylline Levels and Effects while Breastfeeding
Summary of Use during Lactation
Limited data indicate that pentoxifylline is poorly excreted into breastmilk. It would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months.
Drug Levels
Maternal Levels. Five women who had been breastfeeding for at least 6 weeks received a single 400 mg oral dose of a sustained-release form of pentoxifylline. The average total milk concentration of pentoxifylline plus its 3 active metabolites was 419 mcg/L at 2 hours after the dose and 982 mcg/L at 4 hours.[1] Using the peak milk level data from this study, an exclusively breastfed infant would receive an estimated maximum of 147 mcg/kg daily with this maternal dosage regimen or about 2% of the maternal weight-adjusted dosage. Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Possible Effects on Lactation
Relevant published information was not found as of the revision date.
References
1. Witter FR, Smith RV. The excretion of pentoxifylline and its metabolites into human breast milk. Am J Obstet Gynecol. 1985;151:1094-7. PMID: 3985069
Pentoxifylline Identification
Substance Name
CAS Registry Number
6493-05-6
Drug Class
- Hematologic Agents
- Phosphodiesterase Inhibitors
- Platelet Aggregation Inhibitors
- Xanthines
Administrative Information
LactMed Record Number
504
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
2007-12-27
Disclaimer
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
See Also...
- Pentoxifylline use during Pregnancy
- Pentoxifylline Consumer Information
- Breastfeeding Support Group
- Safe Medications during Breastfeeding
- Medicine use while Breastfeeding
- Medicine use during Pregnancy
Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.
