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Pamidronate

Pronunciation

Generic Name: pamidronate (PAM-i-DROE-nate)
Brand Name: Aredia

Pamidronate is used for:

Treating high calcium levels in the blood due to cancer. It is also used to treat Paget disease of the bone and bone tumors caused by certain cancers. It may also be used for other conditions as determined by your doctor.

Pamidronate is a bisphosphonate. It works by reducing normal and abnormal bone loss, which helps to maintain bone strength. This also helps to reduce the amount of calcium in the blood in situations in which the levels of blood calcium may be too high.

Do NOT use pamidronate if:

  • you are allergic to any ingredient in pamidronate or to other bisphosphonates (eg, alendronate)

Contact your doctor or health care provider right away if any of these apply to you.

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Before using pamidronate:

Some medical conditions may interact with pamidronate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have stomach or bowel problems, low calcium blood levels, blood problems (eg, anemia, low blood platelet levels, low white blood cell counts), kidney problems, asthma, or dental problems
  • if you have had thyroid surgery or have low parathyroid hormone levels
  • if you are using chemotherapy or radiation

Some MEDICINES MAY INTERACT with pamidronate. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Corticosteroids (eg, prednisone) because the risk of jaw bone problems may be increased
  • Thalidomide or medicines that may harm the kidney (eg, aminoglycosides [eg, amikacin, gentamicin], amphotericin B, cyclosporine, nonsteroidal anti-inflammatory drugs [NSAIDs] [eg, ibuprofen], tacrolimus, vancomycin) because the risk of kidney side effects may be increased. Ask your doctor if you are unsure if any of your medicines might harm the kidney

This may not be a complete list of all interactions that may occur. Ask your health care provider if pamidronate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use pamidronate:

Use pamidronate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Pamidronate is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using pamidronate at home, a health care provider will teach you how to use it. Be sure you understand how to use pamidronate. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use pamidronate if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of pamidronate, contact your doctor right away.

Ask your health care provider any questions you may have about how to use pamidronate.

Important safety information:

  • Pamidronate may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use pamidronate with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Talk with your doctor about whether you should take a calcium and vitamin D supplement while you use pamidronate. Do not start a calcium and vitamin D supplement without first checking with your doctor. Do not take a calcium and vitamin D supplement if you have high blood calcium levels.
  • Pamidronate may cause jaw bone problems in some patients. Your risk may be greater the longer you take pamidronate or if you have cancer, poor dental hygiene, ill-fitting dentures, or certain other conditions (eg, anemia, blood clotting problems, dental problems, infection). Your risk may also be greater if you have certain dental procedures or you use certain medicines or therapies (eg, chemotherapy, corticosteroids, radiation). Talk to your doctor about having a dental exam before you start to use pamidronate. Ask your doctor any questions you may have about dental treatment while you use pamidronate.
  • Certain dental procedures should be avoided if possible while you are using pamidronate.
  • Proper dental care is important while you are taking pamidronate. Brush and floss your teeth and visit the dentist regularly.
  • Worsening of asthma has been reported in patients taking medicines like this one. Discuss any questions or concerns with your doctor.
  • Lab tests, including kidney function tests, complete blood cell counts, and calcium, phosphate, magnesium, and potassium blood levels, may be performed while you use pamidronate. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use pamidronate with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use pamidronate if you are pregnant. It may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. You will need to discuss the benefits and risks of using pamidronate while you are pregnant. It is not known if pamidronate is found in breast milk. If you are or will be breast-feeding while you use pamidronate, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of pamidronate:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; constipation; coughing; dizziness; drowsiness; headache; increased sweating; indigestion; loss of appetite; mild bone, joint, or muscle pain; mild fever for 24 to 48 hours; nausea; stomach pain; stuffy or runny nose; trouble sleeping; unusual tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); confusion; decreased urination; fainting; fast or irregular heartbeat; frequent or painful urination; hallucinations; jaw pain or swelling; mental or mood changes; muscle cramps or spasms; numbness or tingling of the skin; pain, swelling, or redness at injection site; persistent or high fever; seizures; severe or persistent stomach pain, headache, or dizziness; severe or persistent tiredness or weakness; severe or prolonged bone, joint, or muscle pain; shortness of breath; vision changes; white patches in the mouth.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include high fever; lightheadedness; muscle cramps or spasms; taste changes.

Proper storage of pamidronate:

Pamidronate is usually handled and stored by a health care provider. If you are using pamidronate at home, store pamidronate as directed by your pharmacist or health care provider. Keep pamidronate out of the reach of children and away from pets.

General information:

  • If you have any questions about pamidronate, please talk with your doctor, pharmacist, or other health care provider.
  • Pamidronate is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take pamidronate or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about pamidronate. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to pamidronate. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using pamidronate.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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