Pamidronate Dosage

This dosage information may not include all the information needed to use Pamidronate safely and effectively. See additional information for Pamidronate.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Hypercalcemia of Malignancy

60 to 90 mg as a single dose, intravenously by slow infusion over 2 to 24 hours one time. Longer infusions (i.e., > 2 hours) may reduce the risk for renal toxicity, particularly in patients with preexisting renal insufficiency. If significant hypercalcemia persists or recurs, a second dose, identical to the first, may be considered. A minimum of 7 days should elapse between doses. Response to subsequent doses may be diminished. Patients with frequent recurrences of hypercalcemia may require infusions of pamidronate every 2 to 3 weeks to maintain normocalcemia.

Usual Adult Dose for Paget's Disease

30 mg intravenously as a 4 hour infusion on 3 consecutive days. A limited number of patients have received more than one treatment with the same dosage.

Usual Adult Dose for Osteolytic Bone Lesions of Multiple Myeloma

90 mg intravenously as a 4 hour infusion given on a monthly basis for up to 9 months.

Usual Adult Dose for Osteolytic Bone Metastases of Breast Cancer

90 mg intravenously as a 2 hour infusion given every 3 to 4 weeks.

Usual Pediatric Dose for Hypercalcemia

> 1 year:

0.5 to 1 mg/kg intravenously by slow infusion over 24 hours one time. If significant hypercalcemia persists or recurs, a second dose, identical to the first, may be considered. A minimum of 7 days should elapse between doses.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dialysis

Data not available

Other Comments

Because pamidronate is associated with hypophosphatemia, hypokalemia, hypocalcemia, and hypomagnesemia, careful monitoring of calcium, potassium, phosphate, and magnesium is recommended.

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