Pamidronate Pregnancy and Breastfeeding Warnings
Pamidronate is also known as: Aredia
Pamidronate Pregnancy Warnings
Pamidronate has been assigned to pregnancy category D by the FDA. Animal studies using bolus intravenous pamidronate revealed evidence of maternal toxicity and embryo/fetal effects when administered during organogenesis at doses 0.6 to 8.3 times the highest recommended human dose for a single IV infusion. Pamidronate crosses the placenta in animals and has produced nonteratogenic effects. There are no controlled data in human pregnancy. Pamidronate is considered contraindicated during pregnancy.
Animal studies using oral pamidronate doses of 25 to 100 mg/kg failed to reveal evidence of fetotoxicity or teratogenicity. Daily oral doses of 60 to 150 mg/kg increased the length of gestation and parturition, causing an increase in pup mortality.
Pamidronate Breastfeeding Warnings
Caution is recommended. Excreted into human milk: Unknown Excreted into animal milk: Unknown The effects in the nursing infant are unknown.
A 2000 study demonstrated that pamidronate 30 mg intravenously produced very low levels in breast milk, so absorption by a breastfed infant is unlikely. Withholding nursing for 12 to 24 hours after a dose should ensure little or no exposure of the breastfed infant to pamidronate.
- Pamidronate use while Breastfeeding (in more detail)
- pamidronate Consumer Information
- Pregnancy Support Group
- FDA Pregnancy Categories
- Medicine use during Pregnancy
- Medicine use while Breastfeeding
- Safe Medications during Breastfeeding
Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This drug information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.