Pamidronate Pregnancy and Breast Feeding Warnings

Pamidronate is also known as: Aredia

Overview

Do not use Pamidronate if you are pregnant. It may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. You will need to discuss the benefits and risks of using Pamidronate while you are pregnant. It is not known if Pamidronate is found in breast milk. If you are or will be breast-feeding while you use Pamidronate , check with your doctor. Discuss any possible risks to your baby.

Pamidronate Pregnancy Warnings

Pamidronate has been assigned to pregnancy category D by the FDA. Animal studies using bolus intravenous pamidronate revealed evidence of maternal toxicity and embryo/fetal effects when administered during organogenesis at doses 0.6 to 8.3 times the highest recommended human dose for a single IV infusion. Pamidronate crosses the placenta in animals and has produced nonteratogenic effects. There are no controlled data in human pregnancy. Pamidronate is considered contraindicated during pregnancy.

Animal studies using oral pamidronate doses of 25 to 100 mg/kg failed to reveal evidence of fetotoxicity or teratogenicity. Daily oral doses of 60 to 150 mg/kg increased the length of gestation and parturition, causing an increase in pup mortality.

Pamidronate Lactation Warnings

There are no data on the excretion of pamidronate into human milk. The manufacturer recommends that caution be used when administering pamidronate to nursing women.

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