Generic Name: olanzapine (oh-LAN-za-peen)
Brand Name: Zyprexa Relprevv
Overdose-like side effects (eg, severe drowsiness, coma, confusion, mental changes), uncontrolled muscle movements, stiff or shaky muscles, trouble talking, joint pain, decreased coordination, aggression, dizziness, weakness, high blood pressure, and seizures have occurred in some patients after injection with olanzapine. In most cases, the reaction occurred within 1 to 3 hours after the injection. You will need to be monitored by a health care professional for at least 3 hours after you receive olanzapine. However, these symptoms may develop more than 3 hours after you receive a dose of olanzapine. Tell your doctor right away if you develop any of these symptoms. Discuss any questions or concerns with your doctor.
Olanzapine is an antipsychotic. It may increase the risk of death when used to treat mental problems caused by dementia in elderly patients. Most of the deaths were linked to heart problems or infection. Olanzapine is not approved to treat mental problems caused by dementia.
Olanzapine is used for:
Treating schizophrenia. It may also be used for other conditions as determined by your doctor.
Olanzapine is an atypical antipsychotic. Exactly how it works is not known. It is thought to affect certain substances in the brain.
Do NOT use olanzapine if:
- you are allergic to any ingredient in olanzapine
Contact your doctor or health care provider right away if any of these apply to you.
Before using olanzapine:
Some medical conditions may interact with olanzapine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of seizures, heart problems (eg, fast, slow, or irregular heartbeat; heart failure), an abnormal electrocardiogram (ECG), a heart attack, a stroke or "mini-stroke," blood vessel problems, high blood cholesterol levels, high or low blood pressure, or low white blood cell levels
- if you have a history of liver problems, stomach or bowel problems (eg, decreased muscle movement), enlarged prostate, narrow-angle glaucoma, neuroleptic malignant syndrome (NMS), aspiration pneumonia, or suicidal thoughts or attempts
- if you have Alzheimer disease, bowel blockage, dementia, or trouble swallowing
- if you have diabetes or are very overweight, or if a family member has had diabetes
- if you have had high blood prolactin levels or a history of certain types of cancer (eg, breast, pancreas, pituitary), or if you are at risk of breast cancer
- if you are dehydrated or have low blood volume, drink alcohol, smoke, or will be exposed to high temperatures
- if you have never taken olanzapine by mouth
Some MEDICINES MAY INTERACT with olanzapine. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Tramadol because the risk of seizures may be increased
- Alpha-blockers (eg, doxazosin), diazepam, or medicine for high blood pressure because the risk of low blood pressure and fainting may be increased
- Anticholinergics (eg, scopolamine), benzodiazepines (eg, lorazepam), or fluvoxamine because they may increase the risk of olanzapine's side effects
- Carbamazepine, HIV protease inhibitors (eg, ritonavir), omeprazole, or rifampin because they may decrease olanzapine's effectiveness
- Dopamine receptor agonists (eg, pramipexole) or levodopa because their effectiveness may be decreased by olanzapine
This may not be a complete list of all interactions that may occur. Ask your health care provider if olanzapine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use olanzapine:
Use olanzapine as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Olanzapine comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get olanzapine refilled.
- Olanzapine is usually given as an injection at your doctor's office, hospital, or clinic.
- Do not use olanzapine if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- If you miss a dose of olanzapine, contact your doctor right away.
Ask your health care provider any questions you may have about how to use olanzapine.
Important safety information:
- Olanzapine may cause dizziness or drowsiness. Use olanzapine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do not drink alcohol while you are using olanzapine.
- Talk with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using olanzapine; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
- Olanzapine may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. Tell your doctor or other health care provider if these effects occur.
- Do not become overheated or dehydrated in hot weather or while you are being active; heatstroke may occur.
- If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions. Contact your doctor right away if you think you may be dehydrated.
- Olanzapine may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
- Olanzapine may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
- NMS is a possibly fatal syndrome that can be caused by olanzapine. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.
- Some patients who take olanzapine may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take olanzapine in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, chewing movements, mouth puckering, puffing of cheeks, tongue sticking out) while taking olanzapine.
- Some patients have experienced weight gain while using olanzapine. You may need to have regular weight checks while you use olanzapine.
- Lab tests, including fasting blood glucose, cholesterol, complete blood cell counts, and liver function, may be performed while you use olanzapine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use olanzapine with caution in the ELDERLY; they may be more sensitive to its effects.
- Caution is advised when using olanzapine in CHILDREN; they may be more sensitive to its effects, especially drowsiness, increased cholesterol and lipid levels, increased levels of prolactin (a hormone), and weight gain. Children may need regular weight checks while they take olanzapine.
- Olanzapine should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using olanzapine while you are pregnant. Using olanzapine during the third trimester may result in uncontrolled muscle movements or withdrawal symptoms in the newborn. Discuss any questions or concerns with your doctor. Olanzapine is found in breast milk. Do not breast-feed while using olanzapine.
Possible side effects of olanzapine:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Back pain; constipation; cough; diarrhea; dizziness; drowsiness; dry mouth; headache; increased appetite; lightheadedness; nausea; pain, redness, or swelling at the injection site; sore throat; stuffy nose; tiredness; vomiting; weight gain.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); abnormal thoughts; chest pain; confusion; decreased urination; disorientation; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; increased saliva production or drooling; increased sweating; memory loss; menstrual changes; muscle pain, weakness, or stiffness; new or worsening mental or mood changes (eg, agitation, depression, hallucinations); one-sided weakness; seizures; severe or prolonged drowsiness, dizziness, or headache; shortness of breath; suicidal thoughts or actions; swelling of the hands, legs, or feet; symptoms of high blood sugar (eg, increased thirst, hunger, or urination; unusual weakness); symptoms of high prolactin levels (eg, enlarged breast size, decreased sexual ability, missed menstrual period, nipple discharge); tremor; trouble concentrating, speaking, or swallowing; trouble sitting still; trouble walking or standing; uncontrolled muscle movements (eg, arm or leg movements, twitching of the face or tongue, jerking or twisting); unusual bruising; vision changes; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include abnormal thinking; aggression; agitation; chest pain; coma; confusion; difficult or slurred speech; fainting; fast or irregular heartbeat; fever; mental or mood changes; seizure; severe drowsiness, dizziness, or weakness; severe or persistent headache; slow or shallow breathing; stiff muscles; sweating; trouble walking; uncontrolled muscle movements.Proper storage of olanzapine:
Olanzapine is usually handled and stored by a health care provider. If you are using olanzapine at home, store olanzapine as directed by your pharmacist or health care provider. Keep olanzapine out of the reach of children and away from pets.
- If you have any questions about olanzapine, please talk with your doctor, pharmacist, or other health care provider.
- Olanzapine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take olanzapine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about olanzapine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to olanzapine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using olanzapine.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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