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Lotensin HCT

Generic Name: benazepril/hydrochlorothiazide (ben-AZ-e-pril/HYE-droe-KLOR-oh-THYE-a-zide)
Brand Name: Lotensin HCT

Lotensin HCT may cause injury or death to the fetus if taken during pregnancy. If you think you may be pregnant, contact your doctor right away. If you are planning to become pregnant, talk with your doctor about other treatment options.


Lotensin HCT is used for:

Treating high blood pressure.

Lotensin HCT is an angiotensin-converting enzyme (ACE) inhibitor and thiazide diuretic combination. It works to lower your blood pressure by removing excess fluid from the body and causing blood vessels to relax or widen.

Do NOT use Lotensin HCT if:

  • you are allergic to any ingredient in Lotensin HCT, any other sulfonamide medicine (eg, sulfamethoxazole, glyburide, probenecid), or other ACE inhibitors (eg, lisinopril)
  • you have a history of angioedema (swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or unusual hoarseness)
  • you are unable to urinate
  • you are pregnant
  • you are taking a medicine that contains aliskiren and you also have diabetes or kidney problems. Check with your doctor or pharmacist if you are not sure if a medicine you take contains aliskiren
  • you are also taking dofetilide or ketanserin

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Lotensin HCT:

Some medical conditions may interact with Lotensin HCT. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are able to become pregnant
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of heart problems (eg, heart failure, aortic stenosis), blood vessel problems, blood flow problems, bone marrow problems, kidney problems (eg, renal artery stenosis), liver problems, high cholesterol or lipid levels, diabetes, or gout
  • if you have a history of a stroke, a recent heart attack, a kidney transplant, allergies, or asthma
  • if you have an autoimmune disease (eg, rheumatoid arthritis, lupus, scleroderma)
  • if you are dehydrated, have low blood volume, or low blood pressure
  • if you have high blood potassium levels, low blood sodium levels, or are on a low-salt (sodium) diet
  • if you are receiving treatments to reduce sensitivity to bee or wasp stings
  • if you are having dialysis or apheresis, are scheduled to have surgery, or receive anesthesia
  • if you have recently had a certain type of nerve surgery (sympathectomy)
  • if you have never taken another medicine for high blood pressure

Some MEDICINES MAY INTERACT with Lotensin HCT. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Digoxin, dofetilide, or ketanserin because the risk of irregular heartbeat may be increased
  • Everolimus or sirolimus because the risk of angioedema may be increased
  • Adrenocorticotropic hormone (ACTH), corticosteroids (eg, prednisone), dextran sulfate, diazoxide, diuretics (eg, furosemide), or other medicines for high blood pressure because an increased risk of low blood pressure may occur
  • Aliskiren or angiotensin receptor blockers (ARBs) (eg, losartan) because the risk of certain side effects (eg, serious kidney problems, high blood potassium levels, low blood pressure) may be increased
  • Eplerenone, potassium-sparing diuretics (eg, spironolactone, triamterene), potassium supplements, salt substitutes containing potassium, or trimethoprim because the risk of high blood potassium levels may be increased
  • Certain gold-containing medicines (eg, sodium aurothiomalate) because flushing, nausea, vomiting, and low blood pressure may occur
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, celecoxib, ibuprofen, indomethacin) because the risk of serious damage to the kidneys (eg, decrease in amount of urine, weight gain) may be increased or they may decrease Lotensin HCT's effectiveness
  • Lithium or thiopurines (eg, azathioprine) because the risk of their side effects may be increased by Lotensin HCT
  • Insulin or other diabetes medicines (eg, glyburide) because their effectiveness may be decreased by Lotensin HCT

This may not be a complete list of all interactions that may occur. Ask your health care provider if Lotensin HCT may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Lotensin HCT:

Use Lotensin HCT as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Lotensin HCT by mouth with or without food.
  • If you take cholestyramine or colestipol, ask your doctor or pharmacist how to take it with Lotensin HCT.
  • Taking Lotensin HCT at the same time each day will help you remember to take it.
  • Take Lotensin HCT on a regular schedule to get the most benefit from it.
  • Continue to take Lotensin HCT even if you feel well. Do not miss any doses.
  • If you miss a dose of Lotensin HCT, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Lotensin HCT.

Important safety information:

  • Lotensin HCT may cause dizziness, light-headedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Lotensin HCT with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Lotensin HCT may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Lotensin HCT may cause a serious side effect called angioedema. Black patients may be at greater risk of developing this side effect. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness.
  • Lotensin HCT contains hydrochlorothiazide, a sulfonamide, which can cause certain eye problems (myopia, angle-closure glaucoma). Your risk may be increased if you are allergic to sulfonamide medicines (eg, sulfamethoxazole) or to penicillin antibiotics (eg, amoxicillin). Untreated angle-closure glaucoma can lead to permanent vision loss. If these eye problems occur, symptoms usually occur within hours to weeks of starting Lotensin HCT. Contact your doctor immediately if you experience symptoms such as vision changes (eg, decreased vision clearness) or eye pain.
  • Check with your doctor before you use a salt substitute or a product that has potassium in it.
  • Drink plenty of fluids while taking Lotensin HCT and avoid engaging in activities that cause excessive sweating. Dehydration, excessive sweating, vomiting, or diarrhea may lead to a fall in blood pressure. Contact your health care provider at once if any of these occur.
  • A persistent, unproductive cough may occur. Tell your doctor if this occurs. If caused by Lotensin HCT, recovery is rapid when the medicine is stopped.
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
  • Tell your doctor or dentist that you take Lotensin HCT before you receive any medical or dental care, emergency care, or surgery.
  • Lotensin HCT may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
  • Diabetes patients - Lotensin HCT may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Lotensin HCT may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Lotensin HCT. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Lotensin HCT may interfere with certain lab tests, including parathyroid function. Be sure your doctor and lab personnel know you are taking Lotensin HCT.
  • Lab tests, including blood electrolytes, blood pressure, complete blood cell counts, liver function, and kidney function, may be performed while you take Lotensin HCT. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Lotensin HCT with caution in the ELDERLY; they may be more sensitive to its effects.
  • Lotensin HCT should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Lotensin HCT may cause birth defects and fetal or newborn death if you take it while you are pregnant. Do not become pregnant while you take Lotensin HCT. If you think you may be pregnant, contact your doctor right away. Lotensin HCT is found in breast milk. Do not breast-feed while taking Lotensin HCT.

Possible side effects of Lotensin HCT:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Cough; diarrhea; dizziness or light-headedness when sitting up or standing; fatigue; headache; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty swallowing or breathing; tightness in the chest; swelling of the hands, mouth, face, lips, throat, or tongue, unusual hoarseness); blurred vision or other vision changes (eg, decreased vision clearness); chest pain; dark urine; decrease in the amount of urine produced; decreased sexual ability; dry mouth; eye pain; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; muscle cramps, pain, weakness, or stiffness; red, swollen, blistered, or peeling skin; restlessness; severe drowsiness; severe or persistent cough; severe or persistent dizziness or light-headedness; severe or persistent nausea or vomiting; shortness of breath; stomach pain (with or without nausea or vomiting); symptoms of high blood sugar (eg, fast breathing; flushing; fruit-like breath odor; increase in thirst, hunger, or urination); symptoms of low blood sodium levels (eg, confusion, mental or mood changes, seizures, sluggishness); unusual bruising or bleeding; unusual thirst, tiredness, or weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; severe dizziness or light-headedness; symptoms of dehydration (eg, dry mouth or eyes; decrease in the amount of urine; fast heartbeat; unusual thirst, tiredness, or weakness); symptoms of blood electrolyte problems (eg, confusion; irregular heartbeat; mental or mood changes; muscle pain, weakness, or cramping; seizures; sluggishness).

Proper storage of Lotensin HCT:

Store Lotensin HCT at room temperature, below 86 degrees F (30 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Keep in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Lotensin HCT out of the reach of children and away from pets.

General information:

  • If you have any questions about Lotensin HCT, please talk with your doctor, pharmacist, or other health care provider.
  • Lotensin HCT is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Lotensin HCT or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Lotensin HCT. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Lotensin HCT. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Lotensin HCT.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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