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Lotensin HCT Side Effects

Generic Name: benazepril / hydrochlorothiazide

Note: This page contains information about the side effects of benazepril / hydrochlorothiazide. Some of the dosage forms included on this document may not apply to the brand name Lotensin HCT.

Not all side effects for Lotensin HCT may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to benazepril / hydrochlorothiazide: oral tablet

In addition to its needed effects, some unwanted effects may be caused by benazepril / hydrochlorothiazide. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking benazepril / hydrochlorothiazide:

Less common
  • Blurred vision
  • confusion
  • decreased urination
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fast, slow, or irregular heartbeat
  • muscle cramps or pain
  • numbness, tingling, pain, or weakness in the hands or feet
  • rapid breathing
  • seizures
  • sunken eyes
  • sweating
  • thirst
  • trembling
  • unusual tiredness or weakness
  • weakness and heaviness of the legs
  • wrinkled skin

Some of the side effects that can occur with benazepril / hydrochlorothiazide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Cough
  • decreased interest in sexual intercourse
  • excessive muscle tone
  • feeling of constant movement of self or surroundings
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • muscle stiffness
  • muscle tension or tightness
  • nausea
  • sensation of spinning
  • sleepiness or unusual drowsiness

For Healthcare Professionals

Applies to benazepril / hydrochlorothiazide: oral tablet

General

The most common side effects were dizziness, fatigue, headache, and cough.[Ref]

Nervous system

Common (1% to 10%): Dizziness, postural dizziness, headache, hypertonia, somnolence
Uncommon (0.1% to 1%): Paresthesia, taste perversion, tinnitus, syncope, hypesthesia

Hydrochlorothiazide:
Postmarketing reports: Lightheadedness, headache, paresthesia[Ref]

Respiratory

Common (1% to 10%): Cough, upper respiratory infection, rhinitis, sinusitis
Uncommon (0.1% to 1%): Epistaxis, bronchitis, voice alteration

Benazepril:
Postmarketing reports: Eosinophilic pneumonitis

Hydrochlorothiazide:
Postmarketing reports: Respiratory distress, pneumonitis, pulmonary edema[Ref]

Other

Common (1% to 10%): Fatigue, vertigo, flu syndrome
Uncommon (0.1% to 1%): Asthenia, chest pain, fever, chills

Hydrochlorothiazide:
Postmarketing reports: Vertigo, weakness, pyrexia, asthenia[Ref]

Genitourinary

Common (1% to 10%): Impotence, urinary frequency
Uncommon (0.1% to 1%): Urinary tract infection[Ref]

Gastrointestinal

Common (1% to 10%): Nausea
Uncommon (0.1% to 1%): Vomiting, diarrhea, dyspepsia, constipation, dry mouth, abdominal pain, gastroenteritis, flatulence, tooth disorder

Hydrochlorothiazide:
Postmarketing reports: Pancreatitis, small bowel angioedema, sialadenitis, vomiting, diarrhea, cramping, nausea, gastric irritation, constipation[Ref]

Musculoskeletal

Common (1% to 10%): Back pain
Uncommon (0.1% to 1%): Arthralgia, myalgia, neck pain, arthritis

Hydrochlorothiazide:
Postmarketing reports: Muscle spasm[Ref]

Dermatologic

Uncommon (0.1% to 1%): Rash, sweating, photosensitivity, pruritus, alopecia

Benazepril:
Postmarketing reports: Stevens-Johnson syndrome, pemphigus

Hydrochlorothiazide:
Postmarketing reports: Purpura, urticaria, rash, photosensitivity, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis[Ref]

Psychiatric

Uncommon (0.1% to 1%): Insomnia, nervousness, libido decreased, abnormal dreams

Hydrochlorothiazide:
Postmarketing reports: Restlessness[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Palpitations, flushing, peripheral vascular disorder, tachycardia

Hydrochlorothiazide:
Postmarketing reports: Necrotizing angiitis[Ref]

Ocular

Uncommon (0.1% to 1%): Abnormal vision, retinal disorder, conjunctivitis

Hydrochlorothiazide:
Postmarketing reports: Transient blurred vision, xanthopsia[Ref]

Metabolic

Uncommon (0.1% to 1%): Anorexia

Hydrochlorothiazide:
Postmarketing reports: Anorexia, hyperglycemia, glycosuria, hyperuricemia[Ref]

Immunologic

Uncommon (0.1% to 1%): Infection

Hydrochlorothiazide:
Postmarketing reports: Anaphylactoid reactions[Ref]

Renal

Frequency not reported: Serum creatinine increased, BUN increased[Ref]

Hematologic

Benazepril:
Postmarketing reports: Hemolytic anemia, thrombocytopenia

Hydrochlorothiazide:
Postmarketing reports: Aplastic anemia, agranulocytosis, leukopenia, neutropenia, thrombocytopenia[Ref]

Hepatic

Benazepril:
Postmarketing reports: Pancreatitis

Hydrochlorothiazide:
Postmarketing reports: Intrahepatic cholestatic jaundice[Ref]

Endocrine

Hydrochlorothiazide:
Postmarketing reports: Parathyroid gland changes with hypercalcemia and hypophosphatemia[Ref]

References

1. "Product Information. Lotensin HCT (benazepril-hydrochlorothiazide)." Ciba Pharmaceuticals, Summit, NJ.

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