Questions about Rheumatoid Arthritis? Get answers from our expert.

Hyaluronate sodium

Generic Name: hyaluronate sodium (HYE-a-loo-RON-ate SOE-dee-um)
Brand Name: Euflexxa

Hyaluronate sodium is used for:

Treating knee pain in patients with osteoarthritis who have not received relief from other treatments.

Hyaluronate sodium is a hyaluronic acid derivative. It works by increasing the effectiveness of the fluid within the knee joint to act as a lubricant and shock absorber.

Do NOT use hyaluronate sodium if:

  • you are allergic to any ingredient in hyaluronate sodium or to similar medicines
  • you have a knee joint infection, or an infection or skin disease around the injection site

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: Is it Safe to Give Human Medicine to Pets?

Always get your pet's drug and dose recommendation from the veterinarian.

Before using hyaluronate sodium:

Some medical conditions may interact with hyaluronate sodium. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have received another injectable medicine in the same joint into which hyaluronate sodium will be injected

Some MEDICINES MAY INTERACT with hyaluronate sodium. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Quaternary ammonium salts (eg, benzalkonium chloride) because side effects may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if hyaluronate sodium may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use hyaluronate sodium:

Use hyaluronate sodium as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with hyaluronate sodium. Talk to your pharmacist if you have questions about this information.
  • Hyaluronate sodium is given as an injection into the knee joint at your doctor's office, hospital, or clinic.
  • Hyaluronate sodium is usually given as a series of injections 1 week apart for a total of 3 injections. You may not experience relief until you have received several injections.
  • Do not use hyaluronate sodium if it contains particles, is cloudy or discolored, or if the syringe is cracked or damaged.
  • Do not use disinfectants containing ammonium salts to prepare the skin for injection because side effects may occur.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of hyaluronate sodium, contact your doctor to establish a new dosing schedule.

Ask your health care provider any questions you may have about how to use hyaluronate sodium.

Important safety information:

  • Someone may need to drive you home from the doctor's office, hospital, or clinic after you receive hyaluronate sodium. Discuss any questions or concerns with your doctor.
  • You may experience a temporary inflammation in your knee after using hyaluronate sodium. If the inflammation is severe or continues, contact your doctor.
  • Avoid strenuous activity or prolonged (more than 1 hour) weight-bearing activity (eg, running, tennis, heavy lifting, standing on your feet) for at least 48 hours after you are injected with hyaluronate sodium. Ask your doctor when you should begin physical activities again.
  • Hyaluronate sodium should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant while taking hyaluronate sodium, contact your doctor. You will need to discuss the benefits and risks of using hyaluronate sodium while you are pregnant. It is not known if hyaluronate sodium is found in breast milk. If you are or will be breast-feeding while you use hyaluronate sodium, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of hyaluronate sodium:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; mild bruising, redness, or pain at the injection site; mild stiffness, swelling, warmth, or pain in or around the injected knee; muscle or joint pain; temporary achy feeling.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe or persistent headache or dizziness; severe, persistent, or painful swelling of the injected joint.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of hyaluronate sodium:

Hyaluronate sodium is usually handled and stored by a health care provider. If you are using hyaluronate sodium at home, store hyaluronate sodium as directed by your pharmacist or health care provider. Keep hyaluronate sodium out of the reach of children and away from pets.

General information:

  • If you have any questions about hyaluronate sodium, please talk with your doctor, pharmacist, or other health care provider.
  • Hyaluronate sodium is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take hyaluronate sodium or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about hyaluronate sodium. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to hyaluronate sodium. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using hyaluronate sodium.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

Hide
(web2)