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Carboplatin

Pronunciation

Generic Name: carboplatin (KAR-boe-PLA-tin)
Brand Name: Paraplatin

Carboplatin may cause severe allergic reactions, bone marrow suppression, and anemia. Contact your doctor immediately if you develop symptoms of a severe allergic reaction (eg, rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue), symptoms of infection (eg, fever, chills, sore throat), or unusual bruising or bleeding. Vomiting is a common side effect of carboplatin. Talk with your doctor about ways to decrease this side effect.


Carboplatin is used for:

Treating ovarian cancer. It may also be used for other conditions as determined by your doctor.

Carboplatin is an antineoplastic. It works by disrupting the cell growth of cancer cells, which helps you fight cancer.

Do NOT use carboplatin if:

  • you are allergic to any ingredient in carboplatin, mannitol, or compounds that contain platinum (eg, cisplatin)
  • you have severe bone marrow depression or severe bleeding problems

Contact your doctor or health care provider right away if any of these apply to you.

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Before using carboplatin:

Some medical conditions may interact with carboplatin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have kidney or liver problems
  • if you have low blood electrolyte (eg, sodium, potassium, calcium, magnesium) levels

Some MEDICINES MAY INTERACT with carboplatin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Aminoglycoside antibiotics (eg, gentamicin) and anticoagulants (eg, warfarin) because side effects, including risk of bleeding, kidney problems, or hearing problems, may be increased by carboplatin
  • Medicines that may harm the kidney (eg, amphotericin B, cyclosporine, nonsteroidal anti-inflammatory drugs [NSAIDs] [eg, ibuprofen], tacrolimus, vancomycin) because the risk of kidney side effects may be increased. Ask your doctor if you are unsure if any of your medicines might harm the kidney.
  • Hydantoins (eg, phenytoin) because the effectiveness of these medicines may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if carboplatin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use carboplatin:

Use carboplatin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with carboplatin. Talk to your pharmacist if you have questions about this information.
  • Carboplatin is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using carboplatin at home, a health care provider will teach you how to use it. Be sure you understand how to use carboplatin. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use carboplatin if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • If you spill carboplatin on your skin, wash it off right away with soap and water.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If nausea, vomiting, or loss of appetite occur, ask your doctor or pharmacist for ways to lessen these effects.
  • If you miss a dose of carboplatin, contact your doctor right away.

Ask your health care provider any questions you may have about how to use carboplatin.

Important safety information:

  • If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.
  • Carboplatin may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Carboplatin may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • Do not receive a live vaccine (eg, measles, mumps) while you are taking carboplatin. Talk with your doctor before you receive any vaccine.
  • Women who may become pregnant should use an effective form of birth control while using carboplatin. Check with your doctor if you have questions about effective birth control.
  • Lab tests, including complete blood cell counts, may be performed while you use carboplatin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use carboplatin with caution in the ELDERLY; they may be more sensitive to its effects, especially numbness, tingling, or pain in the hands or feet.
  • Use carboplatin with extreme caution in CHILDREN; safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Carboplatin has been shown to cause harm to the fetus. Avoid becoming pregnant while taking carboplatin. If you think you may be pregnant, discuss with your doctor the benefits and risks of using carboplatin during pregnancy. It is not known if carboplatin is found in breast milk. Do not breast-feed while taking carboplatin.

Possible side effects of carboplatin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; hair loss; loss of appetite; nausea; stomach pain or upset; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in the amount of urine produced; cough; dark urine; decreased hearing or hearing loss; fever, chills, or sore throat; injection-site reactions (eg, redness, swelling, pain); numbness, tingling, or pain of the hands or feet; pain, irritation, or sores in the mouth; ringing in the ears; severe or persistent tiredness or weakness; unusual bruising or bleeding; vision changes or loss; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include loss of vision (which can be complete for light and colors); severe stomach pain; yellowing of skin or eyes.

Proper storage of carboplatin:

Carboplatin is usually handled and stored by a health care provider. If you are using carboplatin at home, store carboplatin as directed by your pharmacist or health care provider.

General information:

  • If you have any questions about carboplatin, please talk with your doctor, pharmacist, or other health care provider.
  • Carboplatin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take carboplatin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about carboplatin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to carboplatin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using carboplatin.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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