Anectine

Generic Name: succinylcholine (SUX-i-nil-KOE-leen)
Brand Name: Examples include Anectine and Quelicin

Anectine has been associated with rapid muscle breakdown resulting in life-threatening heart rhythms, cardiac arrest, and death in children. These children appeared to be healthy, but were later found to have certain undiagnosed muscle problems (eg, Duchenne muscular dystrophy). Male children and children younger than 8 years old seem to be at a higher risk. Cases have also been reported in adolescents. Because it is hard to determine which children may be at risk, Anectine should only be used in an emergency situation.


Anectine is used for:

Relaxing muscles during surgery or when using a breathing machine (ventilator). It is also used to induce anesthesia or when a tube must be inserted in the windpipe. It may also be used for other conditions as determined by your doctor.

Anectine is a depolarizing muscle relaxant. It works by keeping muscles from contracting, which causes paralysis of the muscles in the face and those used to breathe and move.

Do NOT use Anectine if:

  • you are allergic to any ingredient in Anectine
  • you have recently had a severe burn, trauma, nerve damage, or an upper body movement injury
  • you have a personal or family history of muscle disease or malignant hyperthermia (a life-threatening state that includes high body temperatures)

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Anectine:

Some medical conditions may interact with Anectine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to another neuromuscular blocking agent (eg, pancuronium)
  • if you have glaucoma, blood electrolyte problems (eg, high or low potassium levels, low calcium levels), liver or kidney problems, a tumor that has spread, an infection, anemia, a certain thyroid problem (myxedema), stomach or intestinal ulcers, decompensated heart problems, decreased activity or deficiency of plasma cholinesterase, a bone fracture, or muscle spasms
  • if you are dehydrated or have recently had eye surgery or an eye injury
  • if you have or have a history of stomach infections or bleeding in the brain

Some MEDICINES MAY INTERACT with Anectine. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Digoxin because the risk of abnormal heart rhythms may be increased
  • Aminoglycosides (eg, gentamicin), aprotinin, beta-adrenergic blockers (eg, propranolol), chloroquine, clindamycin, cyclophosphamide, glucocorticoids (eg, prednisone), lidocaine, lithium, magnesium salts, metoclopramide, oral contraceptives (eg, birth control pills), oxytocin, procainamide, promazine, quinidine, quinine, terbutaline, or trimethaphan because they may increase the risk of Anectine's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Anectine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Anectine:

Use Anectine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Anectine is given as an injection at your doctor's office, hospital, or clinic.
  • Do not use Anectine if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Anectine, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Anectine.

Important safety information:

  • Malignant hyperthermia is a possibly fatal syndrome that can be caused by Anectine. Symptoms may include fast heartbeat, fast breathing, high body temperature, or spasm or stiffness of the jaw or other muscles. Contact your doctor at once if you have any of these symptoms.
  • Tell your doctor or dentist that you take Anectine before you receive any medical or dental care, emergency care, or surgery.
  • Anectine should only be used in CHILDREN in emergency situations. Rare, serious side effects have occurred in children who have received Anectine.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Anectine while you are pregnant. If you are or will be breast-feeding while you use Anectine, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Anectine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Increased saliva; muscle pain following surgery; muscle twitching.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; fast breathing; fast, slow, or irregular heartbeat; flushing; high body temperature; increased pressure in the eye; pauses in breathing; pounding in the chest; severe muscle pain with or without decreased urination; severe or persistent dizziness or headache; slowed or shallow breathing; tightening of the jaw or other muscles.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include muscle weakness; slowed breathing or pauses in breathing.

Proper storage of Anectine:

Anectine is usually handled and stored by a health care provider. If you are using Anectine at home, store Anectine as directed by your pharmacist or health care provider. Keep Anectine out of the reach of children and away from pets.

General information:

  • If you have any questions about Anectine, please talk with your doctor, pharmacist, or other health care provider.
  • Anectine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Anectine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Anectine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Anectine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Anectine.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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