Vyondys 53 Side Effects

Generic name: golodirsen

Medically reviewed by Drugs.com. Last updated on Apr 19, 2025.

Note: This document provides detailed information about Vyondys 53.

Applies to golodirsen: intravenous solution Side Effects associated with golodirsen. Some dosage forms listed on this page may not apply specifically to the brand name Vyondys 53.

Applies to golodirsen: intravenous solution.

Precautions

Your child's doctor will check your child's progress closely while your child is receiving this medicine. This will allow your child's doctor to see if the medicine is working properly and to decide if your child should continue to receive it.

Serious allergic reactions may occur while your child is receiving this medicine. Tell your child's doctor right away if your child has a fever, hives or rash, blistering, crusting, itching, or reddening of the skin, trouble breathing or swallowing, or unusual tiredness or weakness.

Serious side effects of Vyondys 53

Along with its needed effects, golodirsen (the active ingredient contained in Vyondys 53) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking golodirsen:

Other side effects of Vyondys 53

Some side effects of golodirsen may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to golodirsen: intravenous solution.

General adverse events

The most commonly reported adverse reactions have included headache, pyrexia, falls, abdominal pain, nasopharyngitis, cough, vomiting, and nausea.^[Ref]

Hypersensitivity

• Frequency not reported: Hypersensitivity reactions

Nervous system

• Very common (10% or more): Headache (41%)
• Common (1% to 10%): Dizziness

Gastrointestinal

• Very common (10% or more): Abdominal pain (27%), vomiting (27%), nausea (20%)
• Common (1% to 10%): Diarrhea, oropharyngeal pain, constipation

Local

• Common (1% to 10%): Administration site pain, catheter site related reaction

Immunologic

• Common (1% to 10%): Influenza, seasonal allergy

Musculoskeletal

• Common (1% to 10%): Back pain, ligament strain, fracture

Respiratory

• Very common (10% or more): Nasopharyngitis (27%)
• Common (1% to 10%): Rhinitis

Other

• Very common (10% or more): Pyrexia (41%), fall (29%)
• Common (1% to 10%): Pain, ear infection

Cardiovascular

• Common (1% to 10%): Tachycardia

Dermatologic

• Common (1% to 10%): Contusion, skin abrasion

See also:

Frequently asked questions

• What are the new drugs for DMD (Duchenne muscular dystrophy)?
• How does Vyondys 53 work?
• How long does it take for Vyondys 53 to work?
• How is Vyondys 53 administered?

Further information

Vyondys 53 side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer