Vitamin K1 Side Effects

Generic name: phytonadione

Medically reviewed by Drugs.com. Last updated on Feb 28, 2024.

Note: This document contains side effect information about phytonadione. Some dosage forms listed on this page may not apply to the brand name Vitamin K1.

For Healthcare Professionals

Applies to phytonadione: compounding powder, injectable solution, oral tablet.

Local

Rare (less than 0.1%): Injection site reactions (inflammation, atrophy, necrosis)

Very rare (less than 0.01%): Venous irritation or phlebitis (IV route)

Frequency not reported: Pain, swelling, and tenderness at the injection site^[Ref]

Cardiovascular

Rare (less than 0.1%): Rapid and weak pulse, hypotension, cyanosis

Very rare (less than 0.01%): Facial flushing

Postmarketing reports: Tachycardia, flushing^[Ref]

Hypersensitivity

Very rare (less than 0.01%): Anaphylactoid reactions (IV route)

Frequency not reported: Allergic sensitivity, anaphylaxis

Postmarketing reports: Fatal hypersensitivity reaction^[Ref]

Fatalities and other severe reactions have occurred during or immediately after the parenteral administration of phytonadione. The majority of these reactions have occurred with intravenous administration. These reactions resemble hypersensitivity or anaphylaxis and include shock and cardiac or respiratory arrest. Feelings of uneasiness, flushing, diaphoresis, chest pain, tachycardia, cyanosis, weakness, and dyspnea may precede the cardiopulmonary event. These severe reactions are more likely with, but are not limited to, rapid infusions of undiluted drug.^[Ref]

Gastrointestinal

Gastrointestinal side effects have rarely included 'peculiar' sensations of taste.

Respiratory

Rare (less than 0.1%): Dyspnea^[Ref]

Other

Frequency not reported: Death (IV and IM routes)^[Ref]

Dermatologic

Uncommon (0.1% to 1%): Erythematous, indurated, pruritic plaques

Rare (less than 0.1%): Profuse sweating, scleroderma-like lesions,

Very rare (less than 0.01%): Sweating

Frequency not reported: Erythema perstans-like lesions^[Ref]

Nervous system

Rare (less than 0.1%): Dizziness

Very rare (less than 0.01%): Unusual taste

Postmarketing reports: Dysgeusia^[Ref]

Hepatic

Rare (less than 0.1%): Hyperbilirubinemia

Frequency not reported: Jaundice in newborns^[Ref]

Hyperbilirubinemia occurred primarily with doses above those recommended.^[Ref]

Hematologic

Frequency not reported: Hemolysis in newborns^[Ref]

General

The most common adverse events were dermatologic and injection site reactions.^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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