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Triderma Side Effects

Generic name: fluocinolone / hydroquinone / tretinoin topical

Medically reviewed by Last updated on Feb 26, 2023.

Note: This document contains side effect information about fluocinolone / hydroquinone / tretinoin topical. Some dosage forms listed on this page may not apply to the brand name Triderma.

Applies to fluocinolone/hydroquinone/tretinoin topical: topical application cream.

Serious side effects of Triderma

Along with its needed effects, fluocinolone/hydroquinone/tretinoin topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking fluocinolone / hydroquinone / tretinoin topical:

More common

  • Redness, peeling, drying, itching, or burning of the skin

Less common

  • Darkening of normal skin color
  • irritated skin
  • rash

Incidence not known

  • Blistering, crusting, or flaking of the skin
  • burning and itching of the skin with pinhead-sized red blisters
  • lightening of normal skin color
  • redness and scaling around the mouth
  • severe redness, soreness, or scaling of the skin
  • thinning of the skin with easy bruising

Other side effects of Triderma

Some side effects of fluocinolone / hydroquinone / tretinoin topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Blemishes on the skin
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • pimples
  • raised, dark red, wart-like spots on the skin

For Healthcare Professionals

Applies to fluocinolone / hydroquinone / tretinoin topical: topical cream.


The most commonly reported side effects included erythema, desquamation, burning, and dryness.[Ref]


Very common (10% or more): Erythema (up to 41%), desquamation (up to 38%), dryness (up to 14%), pruritus (up to 11%)

Common (1% to 10%): Acne, telangiectasia, rosacea, papules, acne-like rash, rash, vesicles, pigmentary changes

Postmarketing reports: Itching, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, secondary infection, skin atrophy, striae, miliaria, allergic contact dermatitis[Ref]

Nervous system

Very common (10% or more): Burning (18%)

Common (1% to 10%): Paresthesia[Ref]


Common (1% to 10%): Irritation[Ref]


Common (1% to 10%): Dry mouth[Ref]

More about Triderma (fluocinolone / hydroquinone / tretinoin topical)

Patient resources

Other brands


Professional resources

Related treatment guides


1. "Product Information. Tri-Luma (fluocinolone / hydroquinone / tretinoin topical)." Galderma Laboratories Inc (2003):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.