Triderma Side Effects

Generic name: fluocinolone / hydroquinone / tretinoin topical

Medically reviewed by Drugs.com. Last updated on Jan 17, 2025.

Note: This document provides detailed information about Triderma Side Effects associated with fluocinolone / hydroquinone / tretinoin topical. Some dosage forms listed on this page may not apply specifically to the brand name Triderma.

Applies to fluocinolone/hydroquinone/tretinoin topical: topical application cream.

Serious side effects of Triderma

Along with its needed effects, fluocinolone/hydroquinone/tretinoin topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking fluocinolone / hydroquinone / tretinoin topical:

More common side effects

• redness, peeling, drying, itching, or burning of the skin

Less common side effects

• darkening of normal skin color
• irritated skin
• rash

Incidence not known

• blistering, crusting, or flaking of the skin
• burning and itching of the skin with pinhead-sized red blisters
• lightening of normal skin color
• redness and scaling around the mouth
• severe redness, soreness, or scaling of the skin
• thinning of the skin with easy bruising

Other side effects of Triderma

Some side effects of fluocinolone / hydroquinone / tretinoin topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• blemishes on the skin
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• pimples
• raised, dark red, wart-like spots on the skin

For healthcare professionals

Applies to fluocinolone / hydroquinone / tretinoin topical: topical cream.

General adverse events

The most commonly reported side effects included erythema, desquamation, burning, and dryness.^[Ref]

Dermatologic

• Very common (10% or more): Erythema (up to 41%), desquamation (up to 38%), dryness (up to 14%), pruritus (up to 11%)
• Common (1% to 10%): Acne, telangiectasia, rosacea, papules, acne-like rash, rash, vesicles, pigmentary changes
• Postmarketing reports: Itching, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, secondary infection, skin atrophy, striae, miliaria, allergic contact dermatitis^[Ref]

Nervous system

• Very common (10% or more): Burning (18%)
• Common (1% to 10%): Paresthesia^[Ref]

Local

• Common (1% to 10%): Irritation^[Ref]

Gastrointestinal

• Common (1% to 10%): Dry mouth^[Ref]

Further information

Triderma side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer