Thiabendazole Side Effects
Applies to thiabendazole: compounding powder, oral suspension, oral tablet chewable
Gastrointestinal side effects have commonly included nausea, vomiting, anorexia, and abdominal pain. These side effects generally only last 1 to 2 days and do not require drug discontinuation. Epigastric distress and abdominal pain have also been reported.[Ref]
Nervous system side effects have included drowsiness, dizziness, giddiness, headache, paresthesias, weariness, numbness, hyperirritability, convulsions, collapse, confusion, depression, floating sensation, weakness, and lack of coordination.[Ref]
Erythema multiforme (including Stevens-Johnson syndrome) and toxic epidermal necrolysis generally do not occur for several weeks after thiabendazole is discontinued. The reaction generally starts with a skin eruption which quickly progresses. Two reported cases had complete recovery after several weeks of therapy.[Ref]
Hypersensitivity adverse effects have included pruritic rash reactions, fever, facial flush, chills, conjunctival injection, angioedema, anaphylaxis, skin rashes (including perianal), erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis, and lymphadenopathy.[Ref]
Sicca complex has been frequently noted with the hepatic changes associated with thiabendazole. This clinical picture includes keratoconjunctivitis sicca and xerostomia. This also appears to be reversible in most cases without medical intervention.[Ref]
Hepatic side effects reported have included liver damage. It may manifest as jaundice, cholestasis, sicca syndrome, malaise, light-colored stools, and gastrointestinal upset. These symptoms generally do not occur for several weeks following thiabendazole therapy completion. Therapy usually consists of only supportive measures. In most cases the hepatic damage is reversible, although at least one patient has died as a result of hepatic damage. Sicca complex has also been reported.[Ref]
Ocular side effects have included abnormal sensation in eyes, xanthopsia, blurred vision, and transient disturbances in vision.
Cardiovascular side effects have included hypotension.
Metabolic side effects have included hyperglycemia.
Hematologic side effects have included transient leukopenia.
Psychiatric side effects have included psychic alterations.
Other side effects have included tinnitus, drying of mucous membranes, and live Ascaris in the mouth and nose.
More about thiabendazole
Related treatment guides
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Some side effects may not be reported. You may report them to the FDA.