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Surfaxin Side Effects

Generic Name: lucinactant

Note: This document contains side effect information about lucinactant. Some of the dosage forms listed on this page may not apply to the brand name Surfaxin.

In Summary

Common side effects of Surfaxin include: sepsis, bradycardia, hypotension, and oxygen desaturation. Other side effects include: pneumothorax. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to lucinactant: intratracheal suspension

Along with its needed effects, lucinactant (the active ingredient contained in Surfaxin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking lucinactant:

More common Incidence not known
  • Blue or white in color
  • heart may stop
  • no oxygen to lungs
  • patient unresponsive

Some side effects of lucinactant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • clay-colored stools
  • coma
  • convulsions
  • dark urine
  • decreased urine output
  • fruit-like breath odor
  • loss of appetite
  • rapid, deep breathing
  • rash
  • restlessness
  • sweating
  • swelling of the face, ankles, or hands
  • unusual bleeding or bruising
  • vomiting of blood
  • yellow eyes or skin

For Healthcare Professionals

Applies to lucinactant: intratracheal suspension


Very common (10% or more): Patent ductus arteriosus (up to 43%), hypotension (at least 10%), bradycardia (at least 10%)
Common (1% to 10%): Pallor (up to 10%)[Ref]


Very common (10% or more): Necrotizing enterocolitis (up to 17%)[Ref]


Very common (10% or more): Anemia (at least 10%)[Ref]


Very common (10% or more): Jaundice (at least 10%)


Very common (10% or more): Metabolic acidosis (at least 10%), hyperglycemia (at least 10%), hyponatremia (at least 10%)[Ref]

Nervous system

Very common (10% or more): Intraventricular hemorrhage (up to 52%)
Common (1% to 10%): Periventricular leukomalacia (up to 10%)[Ref]


Very common (10% or more): Retinopathy of prematurity (up to 32%)[Ref]


Very common (10% or more): Acquired sepsis (up to 45%)


Very common (10% or more): Apnea (up to 66%), endotracheal tube reflux (up to 27%), endotracheal tube obstruction (up to 16%), pulmonary air leak (up to 15%), oxygen desaturation (at least 10%), pneumonia (at least 10%)
Common (1% to 10%): Pulmonary hemorrhage (up to 10%), respiratory acidosis (up to 10%), pulmonary interstitial emphysema (up to 9%), pneumothorax (up to 4%)[Ref]


1. "Product Information. Surfaxin (lucinactant)." Discovery Laboratories Inc, Warrington, PA.

Some side effects of Surfaxin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.