Skip to Content

Poliovirus vaccine, inactivated Side Effects

For the Consumer

Applies to poliovirus vaccine, inactivated: injection injectable, injection suspension

Along with its needed effects, poliovirus vaccine, inactivated may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking poliovirus vaccine, inactivated:

Symptoms of allergic reaction
  • Difficulty with breathing or swallowing
  • hives
  • itching, especially of the feet or hands
  • reddening of the skin, especially around ears
  • swelling of the eyes, face, or inside of the nose
  • unusual tiredness or weakness (sudden and severe)
More common
  • Fever over 102° F (39° C)

Some side effects of poliovirus vaccine, inactivated may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Irritability
  • loss of appetite
  • tiredness
Less common
  • Itching or skin rash
  • redness, soreness, hard lump, tenderness, or pain at the place of injection

For Healthcare Professionals

Applies to poliovirus vaccine, inactivated: injectable suspension


Very common (10% or more): Injection site pain (34%), local tenderness (29.4%), local swelling (11.4%)
Common (1% to 10%): Local erythema
Uncommon (0.1% to 1%): Injection site mass
Postmarketing reports: Injection site reaction (including injection site rash)[Ref]


Very common (10% or more): Temperature over 102F (38%)
Common (1% to 10%): Persistent crying
Frequency not reported: Death
Postmarketing reports: Pyrexia[Ref]


Very common (10% or more): Irritability (64.5%), tiredness (60.7%) fussiness, sleepiness
Postmarketing reports: Agitation[Ref]


Very common (10% or more): Anorexia (16.6%)[Ref]


Common (1% to 10%): Vomiting, diarrhea[Ref]

Nervous system

Frequency not reported: Guillain-Barre syndrome
Postmarketing reports: Convulsion, febrile convulsion, headache, paresthesia[Ref]


Postmarketing reports: Type I hypersensitivity reaction (including allergic reaction, anaphylactic reaction, and anaphylactic shock)[Ref]


Postmarketing reports: Arthralgia, myalgia[Ref]


Postmarketing reports: Lymphadenopathy[Ref]


Postmarketing reports: Rash, urticaria[Ref]


1. "Product Information. Ipol (poliovirus vaccine, inactivated)." Aventis Pharmaceuticals, Swiftwater, PA.

2. Cerner Multum, Inc. "Australian Product Information." O 0

Some side effects of poliovirus vaccine, inactivated may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.