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Poliovirus vaccine, inactivated Side Effects

For the Consumer

Applies to poliovirus vaccine, inactivated: injection injectable, injection suspension

As well as its needed effects, poliovirus vaccine, inactivated may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking poliovirus vaccine, inactivated, check with your doctor or nurse immediately:

Symptoms of allergic reaction
  • Difficulty with breathing or swallowing
  • hives
  • itching, especially of the feet or hands
  • reddening of the skin, especially around ears
  • swelling of the eyes, face, or inside of the nose
  • unusual tiredness or weakness (sudden and severe)
More common:
  • Fever over 102° F (39° C)

Minor Side Effects

Some poliovirus vaccine, inactivated side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Irritability
  • loss of appetite
  • tiredness
Less common:
  • Itching or skin rash
  • redness, soreness, hard lump, tenderness, or pain at the place of injection

For Healthcare Professionals

Applies to poliovirus vaccine, inactivated: injectable suspension


Local side effects associated with intramuscular administration have included erythema, swelling, and tenderness at the injection site.[Ref]


Other side effects have included fever >102.2 degrees F, irritability, tiredness, and persistent crying in infants following concomitant vaccination with poliovirus and DTP vaccine. The frequency and severity were similar to adverse effects for DTP vaccine alone.[Ref]


Gastrointestinal side effects have included anorexia and vomiting in infants, following concomitant vaccination with poliovirus and DTP vaccine. The frequency and severity were similar to adverse effects for DTP vaccine alone.[Ref]

Nervous system

Nervous system side effects temporally associated with a different inactivated poliovirus vaccine have included Guillain-Barre Barre syndrome.[Ref]


1. "Product Information. Ipol (poliovirus vaccine, inactivated)." Aventis Pharmaceuticals, Swiftwater, PA.

It is possible that some side effects of poliovirus vaccine, inactivated may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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