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Mesna Side Effects

For the Consumer

Applies to mesna: oral tablet

Other dosage forms:

In addition to its needed effects, some unwanted effects may be caused by mesna. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking mesna:

More common:
  • Black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine
  • chest pain
  • chills
  • convulsions
  • cough
  • decreased urination
  • dizziness
  • dry mouth
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • increased thirst
  • irregular heartbeat
  • lightheadedness
  • loss of appetite
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • painful or difficult urination
  • pinpoint red spots on the skin
  • rapid breathing
  • rapid weight gain
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • sunken eyes
  • swelling
  • swollen glands
  • tightness in the chest
  • trouble breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • wrinkled skin
Less common:
  • Blurred vision
  • confusion
  • dizziness dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • rapid breathing
  • sweating
Incidence not known:
  • Coughing or spitting up blood
  • dark urine
  • general tiredness and weakness
  • headache
  • light-colored stools
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat
  • upper right abdominal or stomach pain
  • yellow eyes and skin

Minor Side Effects

Some of the side effects that can occur with mesna may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Abdominal or stomach pain
  • diarrhea
  • difficulty having a bowel movement (stool)
  • hair loss
  • lack or loss of strength
  • sleepiness or unusual drowsiness
  • weight loss
Less common:
  • Acid or sour stomach
  • back pain
  • belching
  • feeling of warmth
  • heartburn
  • increased sweating
  • indigestion
  • redness of the face, neck, arms, and occasionally, upper chest
  • stomach discomfort or upset
  • trouble sleeping
Incidence not known:
  • Change or loss of taste

For Healthcare Professionals

Applies to mesna: injectable solution, intravenous kit, oral tablet

Gastrointestinal

Very common (10% or more): Nausea (65%), vomiting (35%), constipation (28%), anorexia (21%), abdominal pain/colic (14%), diarrhea
Common (1% to 10%): Dyspepsia, dehydration, anorexia, mucosal irritation, flatulence, burning pain (substernal/epigastric), gingival bleeding
Frequency not reported: Dry mouth, bad taste
Postmarketing reports: Dysgeusia[Ref]

Hypersensitivity

Very common (10% or more): Leukopenia (25%), thrombocytopenia (21%), anemia (20%), granulocytopenia (16%)
Common (1% to 10%): Lymphadenopathy
Frequency not reported: Activated partial thromboplastin time prolonged
Postmarketing reports: Decrease in lymphocyte count (generally reversible within one week)[Ref]

Nervous system

Very common (10% or more): Lightheadedness, lethargy/drowsiness
Common (1% to 10%): Dizziness, headache, pain, somnolence, paresthesia, hyperesthesia, syncope, hypoesthesia, attention disturbance
Postmarketing reports: Convulsion[Ref]

Cardiovascular

Very common (10% or more): Chest pain (10%)
Common (1% to 10%): Hypotension, tachycardia, palpitations
Postmarketing reports: Hypertension[Ref]

Musculoskeletal

Common (1% to 10%): Back pain, arthralgia, myalgia, pain in extremity, pain in jaw
Frequency not reported: Rigors[Ref]

Metabolic

Very common (10% or more): Hypokalemia (10%)[Ref]

Renal

Frequency not reported: Acute renal failure[Ref]

Other

Very common (10% or more): Fatigue (24%), fever (24%), asthenia (15%), flushing
Common (1% to 10%): Edema, peripheral edema, facial edema, pallor, insomnia, nightmares
Frequency not reported: Fever, malaise[Ref]

Dermatologic

Very common (10% or more): Alopecia (12%), rash
Common (1% to 10%): Hyperhidrosis, pruritus
Frequency not reported: Erythema multiforme, drug rash, ulcerations and/or bullae/blistering, angioedema, urticaria, burning sensation, erythema[Ref]

Genitourinary

Common (1% to 10%): Hematuria, dysuria[Ref]

Hepatic

Postmarketing reports: Hepatitis[Ref]

Immunologic

Common (1% to 10%): Pneumonia
Frequency not reported: Influenza-like symptoms[Ref]

Local

Very common (10% or more): Infusion site pruritus, infusion site rash
Common (1% to 10%: Infusion site pain, infusion site erythema, infusion site urticaria, infusion site swelling[Ref]

Ocular

Common (1% to 10%): Conjunctivitis, photophobia, blurred vision[Ref]

Psychiatric

Common (1% to 10%): Anxiety, confusion[Ref]

Respiratory

Very common (10% or more): Dyspnea (11%)
Common (1% to 10%): Cough, nasal congestion, pleuritic pain, bronchospasm, laryngeal discomfort, epistaxis
Frequency not reported: Pharyngitis, rhinitis, respiratory distress, hypoxia
Postmarketing reports: Hemoptysis[Ref]

References

1. Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online. Available from: URL: http://www.appco.com.au/appguide/default.asp." ([2006]):

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Mesnex (mesna)." Bristol-Myers Squibb, Princeton, NJ.

Not all side effects for mesna may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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