Marcaine Spinal Side Effects
Generic name: bupivacaine
Medically reviewed by Drugs.com. Last updated on Jun 17, 2023.
Note: This document contains side effect information about bupivacaine. Some dosage forms listed on this page may not apply to the brand name Marcaine Spinal.
Applies to bupivacaine: implantation implant. Other dosage forms:
Serious side effects of Marcaine Spinal
Along with its needed effects, bupivacaine (the active ingredient contained in Marcaine Spinal) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking bupivacaine:
- shakiness in the legs, arms, hands, or feet
- swelling or discharge where the implant is placed
Incidence not known
- blurred vision
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- chest pain or discomfort
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast, slow, pounding, or irregular heartbeat or pulse
- flushing, redness of the skin
- lightheadedness, dizziness, or fainting
- no blood pressure or pulse
- skin rash, itching, hives, or welts
- unusual tiredness or weakness
- unusually warm skin
Other side effects of Marcaine Spinal
Some side effects of bupivacaine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Change in taste
- loss of taste
- numbness in the mouth
For Healthcare Professionals
Applies to bupivacaine: compounding powder, injectable kit, injectable solution, intrathecal solution, intravenous solution, parenteral implant.
The most frequently reported side effects are acute adverse experiences which demand immediate countermeasures are related to the central nervous system and the cardiovascular system. A major cause of adverse reactions is excessive plasma levels, which may be due to overdose, unintentional intravascular injection, or slow metabolic degradation. It is also difficult to distinguish adverse reactions caused by the drug per se from the physiological effects of the nerve block (e.g. decrease in blood pressure, bradycardia, temporary urinary retention), events caused directly (e.g. spinal hematoma) or indirectly (e.g. meningitis, epidural abscess) by needle puncture or events associated to cerebrospinal leakage (e.g. postdural puncture headache).[Ref]
Very common (10% or more): Hypotension, bradycardia
Common (1% to 10%): Hypertension
Rare (less than 0.1%): Cardiac arrest, cardiac arrhythmia
Common (1% to 10%): Paresthesia, postdural puncture headache, dizziness
Uncommon (0.1% to 1%): Paresis, dysesthesia, convulsion, circumoral paresthesia, unconsciousness, tremor, lightheadedness, dysarthria
Very common (10% or more): Nausea
Common (1% to 10%): Vomiting
Frequency not reported: Persistent anesthesia[Ref]
Common (1% to 10%): Urinary retention, urinary incontinence
Frequency not reported: Loss of perineal sensation, loss of sexual function[Ref]
Rare (less than 0.1%): Respiratory depression
Uncommon (0.1% to 1%): Hyperacusis, tinnitus
Frequency not reported: Alkaline phosphatase increased, bilirubin increased, chills, weakness, septic meningitis, labor delayed, temperature elevated, forceps delivery increased, sensation of heat, cold/numbness[Ref]
Rare (less than 0.1%): Allergic reaction, anaphylactic shock
Uncommon (0.1% to 1%): Vision disturbed
Rare (less than 0.1%): Diplopia
Frequency not reported: Blurred vision, pupils constricted[Ref]
Frequency not reported: Restlessness, anxiety, depression, agitation, nervousness, apprehension, euphoria, confusion[Ref]
Frequency not reported: Hepatic dysfunction, ALT increased, AST increased[Ref]
Uncommon (0.1% to 1%): Muscle weakness, back pain, muscle twitching
Frequency not reported: Joint pain, stiffness, loss of motion
Postmarketing reports: Chondrolysis[Ref]
More about Marcaine Spinal (bupivacaine)
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- Drug class: local injectable anesthetics
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Related treatment guides
1. Cerner Multum, Inc. UK Summary of Product Characteristics.
2. Cerner Multum, Inc. Australian Product Information.
3. Product Information. Marcaine HCl (bupivacaine). Hospira Inc. 2008.
4. Product Information. Bupivacaine Hydrochloride, Spinal (bupivacaine). Claris Lifesciences Inc. 2017.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.