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Lutropin Alfa Side Effects

Medically reviewed by Drugs.com. Last updated on Sep 30, 2023.

Applies to lutropin alfa: subcutaneous powder for solution.

Serious side effects of lutropin alfa

Along with its needed effects, lutropin alfa may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking lutropin alfa:

More common side effects

  • bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • bloating
  • diarrhea
  • stomach or pelvic discomfort, aching, or heaviness

Incidence not known (Observed after pregnancy)

Incidence not known (Observed during menotropin therapy)

Get emergency help immediately if any of the following symptoms of overdose occur while taking lutropin alfa:

Symptoms of overdose

Other side effects of lutropin alfa

Some side effects of lutropin alfa may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • bloated or full feeling
  • breast pain
  • excess air or gas in the stomach or intestines
  • headache
  • pain
  • passing gas
  • unusual tiredness or weakness

Less common side effects

  • body aches or pain
  • chills
  • cough
  • cramps
  • difficulty having a bowel movement (stool)
  • difficulty with breathing
  • ear congestion
  • fever
  • heavy bleeding
  • loss of voice
  • nasal congestion
  • ovarian disorder
  • pain
  • runny nose
  • sneezing
  • sore throat

For healthcare professionals

Applies to lutropin alfa: subcutaneous powder for injection.

General adverse events

The most commonly reported adverse events reported have included headache, pelvic and abdominal pain, nausea, injection site reactions, and mild or moderate ovarian hyperstimulation syndrome (OHSS).[Ref]

Endocrine

Local

During clinical trials, 7.4% of patients reported mild and moderate injection site reactions consisting of bruising, pain, redness, itching, or swelling; there were no reports of severe injection site reactions[Ref]

Genitourinary

Gastrointestinal

Cardiovascular

Musculoskeletal

Nervous system

Respiratory

Hypersensitivity

Mild to severe hypersensitivity reactions including anaphylactic reactions and shock have been reported.

Immunologic

Ocular

Psychiatric

Oncologic

There have been reports of ovarian and other reproductive system neoplasms, both benign and malignant, in women who have undergone multiple treatment regimens for infertility. It has not been established whether or not treatment with gonadotropins increases the risk of these tumors in infertile women.

Other

Dermatologic

References

1. (2004) "Product Information. Luveris (lutropin alfa)." Serono Laboratories Inc

2. Cerner Multum, Inc. "Australian Product Information."

3. Cerner Multum, Inc. (2015) "Canadian Product Information."

Further information

Lutropin alfa side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.