Lutropin alfa Side Effects
Medically reviewed by Drugs.com. Last updated on Aug 24, 2020.
For the Consumer
Applies to lutropin alfa: parenteral injection
Side effects include:
For Healthcare Professionals
Applies to lutropin alfa: subcutaneous powder for injection
The most commonly reported adverse events reported have included headache, pelvic and abdominal pain, nausea, injection site reactions, and mild or moderate ovarian hyperstimulation syndrome (OHSS).[Ref]
Common (1% to 10%): Ovarian hyper-stimulation syndrome (OHSS), ovarian cyst, breast pain, pelvic pain
Frequency not reported: Abortion, breast enlargement, endometrial disorder, genital edema, hemorrhage in pregnancy, leucorrhoea, pelvic pain, pelvic congestion, ectopic pregnancy, premenstrual tension, uterine disorder not otherwise specified, uterine spasm, vaginal candidiasis, vaginal hemorrhage, vaginitis
Common (1% to 10%): Injection site reactions[Ref]
During clinical trials, 7.4% of patients reported mild and moderate injection site reactions consisting of bruising, pain, redness, itching, or swelling; there were no reports of severe injection site reactions[Ref]
Common (1% to 10%): Dysmenorrhea
Frequency not reported: Tooth caries[Ref]
Very rare (less than 0.01%): Thromboembolism
Frequency not reported: Vasodilation[Ref]
Common (1% to 10%): Headache
Mild to severe hypersensitivity reactions including anaphylactic reactions and shock have been reported.
Very rare (less than 0.01%): Hypersensitivity reactions
Frequency not reported: Herpes simplex, infection, influenza-like symptoms, Klebsiella
Frequency not reported: Conjunctivitis
There have been reports of ovarian and other reproductive system neoplasms, both benign and malignant, in women who have undergone multiple treatment regimens for infertility. It has not been established whether or not treatment with gonadotropins increases the risk of these tumors in infertile women.
Frequency not reported: Neoplasms
Frequency not reported: Fever, not otherwise specified; fever
1. "Product Information. Luveris (lutropin alfa)." Serono Laboratories Inc, Rockland, MA.
2. Cerner Multum, Inc. "Canadian Product Information." O 0 (2015):
3. Cerner Multum, Inc. "Australian Product Information." O 0
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Some side effects may not be reported. You may report them to the FDA.